| 100% | MELBLANC | 8 | The voice of 15-Across and many other Looney Tunes characters: 2 wds. |
| 52% | ELMERFUDD | 9 | Looney Tunes character who chases the "wabbit" 15-Across (2 wds.) |
| 52% | YOSEMITESAM | 11 | Looney Tunes character who chases the "varmint" 15-Across (2 wds.) |
| 50% | FAMILYGUY | 9 | Seth MacFarlane animated series featuring the voices of 15-Across, 26-Across, and 34-Across that debuted in 1999 (2 wds.) |
| 50% | DAFFYDUCK | 9 | Best friend and occasional rival of 15-Across, the iconic black duck from "Looney Tunes": 2 wds. |
| 47% | WILLARNETT | 10 | Voice of the title character on 36-Across: 2 wds. |
| 45% | BUGSBUNNY | 9 | Looney Tunes character pursued by 28-Across and 45-Across (2 wds.) |
| 43% | SIDNEYPOITIER | 13 | Star of 15- and 34-Across who won an Oscar for "Lilies of the Field": 2 wds. |
| 42% | BRITNEYSPEARS | 13 | Singer of 15-Across and 50-Across known as the "Princess of Pop" (2 wds.) |
| 42% | WRECKITRALPH | 12 | 2012 animated film featuring the voices of John C. Reilly and Sarah Silverman: 2 wds. |
| 42% | SOUL | 4 | Pixar film starring the voices of 15-Across, 30-Across, 47-Across, and Tina Fey |
| 41% | JUDYGARLAND | 11 | Mickey Rooney's costar in 18-Across and many other movies: 2 wds. |
| 41% | IDINAMENZEL | 11 | The voice of Elsa the Snow Queen in 32-Across: 2 wds. |
| 40% | CARMENSANDIEGO | 14 | Netflix animated adventure series featuring the voice of 49-Across as the title character (2 wds.) |
| 40% | GREENDAY | 8 | 15-Across and 47-Across punk band inducted into the Rock and Roll Hall of Fame in 2015 (2 wds.) |
| 40% | KRISTENBELL | 11 | The voice of Princess Anna in 32-Across: 2 wds. |
| 39% | DIERKSBENTLEY | 13 | Singer of 15-Across and 29-Across who was awarded the 2018 Academy of Country Music's Merle Haggard Spirit Award (2 wds.) |
| 39% | LUKECOMBS | 9 | 15-Across and 33-Across singer who won the 2019 Country Music Association's New Artist of the Year Award (2 wds.) |
| 39% | LUCYLIU | 7 | 15-Across, 20-Across, and 36-Across actress who voices Master Viper in the "Kung Fu Panda" films (2 wds.) |
| 39% | LEFTBRAIN | 9 | Logical and more analytical part of the thinking organ (2 wds) |
| 38% | FAMILYGUY | 9 | Animated TV series featuring the voices of Seth MacFarlane and 43-Across (2 wds.) |
| 38% | FAMILYGUY | 9 | Animated TV series featuring the voices of Seth MacFarlane and 42-Across (2 wds.) |
| 38% | LADYGAGA | 8 | Singer of 15-Across, 9-Down, and 22-Down who will appear in the 2018 remake of "A Star Is Born" (2 wds.) |
| 38% | TOMHIDDLESTON | 13 | "Loki" star who was a schoolmate of 15-Across and 32-Across at Eton College: 2 wds. |
| 37% | ERICIDLE | 8 | Cocreator and lyricist of 15-Across: 2 wds. |
| 37% | DOWNUNDER | 9 | Bravo/Peacock spin-off of 15-Across since 2022, set off the coast of Australia: 2 wds. |
| 37% | BRANDONTAYLOR | 13 | Alabama-born writer of 15-Across and 26-Across/27-Across (2 wds.) |
| 37% | SETHGREEN | 9 | He provides the voice of Chris on "Family Guy": 2 wds. |
| 37% | ALEXBORSTEIN | 12 | She provides the voice of Lois on "Family Guy": 2 wds. |
| 37% | MILAKUNIS | 9 | She provides the voice of Meg on "Family Guy": 2 wds. |