| 100% | BATH | 4 | The Wife of ___ (title character in one of the stories in The Canterbury Tales) |
| 54% | CAT | 3 | The title character of the short story “Tobermory,” for one |
| 53% | REASON | 6 | One of the 13 in the popular Netflix title |
| 51% | DONN | 4 | Arabella —, wife of the title character in 1895 Thomas Hardy novel Jude the Obscure |
| 51% | DANIELKALUUYA | 13 | Actor who plays Slim, one of the title characters on the run in 2019's "Queen & Slim": 2 wds. |
| 51% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 51% | HEADLINES | 9 | The titles of top stories in the news |
| 50% | ESME | 4 | Title heroine in one of 50-Across' "Nine Stories" |
| 50% | ANTONIO | 7 | Title character in Shakespeare play The Merchant of Venice |
| 50% | WARREN | 6 | With 35-Across, actor who played Clyde, one of the title characters on the run in 1967's "Bonnie and Clyde" |
| 49% | ANNEHATHAWAY | 12 | "Interstellar" actress who appears in one of the stories on 27-Across (2 wds.) |
| 49% | IAMB | 4 | One of two in The Winter's Tale |
| 49% | JOHNSLATTERY | 12 | "Mad Men" actor who appears in one of the stories on 27-Across (2 wds.) |
| 48% | UNCAS | 5 | Title character in the J F Cooper novel The Last of the Mohicans |
| 48% | UNCAS | 5 | Title character in 1826 J F Cooper novel The Last of the Mohicans |
| 48% | BATMAN&ROBIN | 12 | 1997 film with George Clooney in one of the title roles |
| 48% | APE | 3 | The title character in "Mighty Joe Young," for one |
| 48% | OGRE | 4 | The title character defeats one in "Puss in Boots" |
| 48% | FRED | 4 | One of the Weasley twins, in the "Harry Potter" stories |
| 48% | ANTONIO | 7 | Title character in William Shakespeare play The Merchant of Venice |
| 48% | TWIN | 4 | One of the two main characters in "The Parent Trap" |
| 47% | KNOX | 4 | One of the two characters in Dr. Seuss' "Fox in Socks" |
| 47% | OPHELIA | 7 | One of the only two female characters in Shakespeare's "Hamlet" |
| 47% | MILLER | 6 | Canterbury Tale teller of the second story |
| 47% | SCOTT | 5 | The manager and one of the main characters in "The Office," Michael ___ |
| 47% | SHOES | 5 | One of the six words in Hemingway’s apocryphal six-word story |
| 46% | KHALEESI | 8 | Title given to the wife of the Dothraki warlord in "Game of Thrones" |
| 46% | RON | 3 | Weasley, one of the main characters in the "Harry Potter" series |
| 46% | CHEM | 4 | One of the subjects that astronaut Story Musgrave has a degree in, for short |
| 46% | ELF | 3 | 2003 film in which the title character exclaims "Son of a nutcracker!" |