| 100% | ICANADD | 7 | They Might Be Giants number with the lyric “Two plus two is four” |
| 44% | LOGICAL | 7 | 2023 Olivia Rodrigo hit with the lyric "Two plus two equals five" |
| 42% | PROS | 4 | They might be denoted with plus signs |
| 41% | ATALE | 5 | "Gigantic (___ of Two Johns)," 2002 documentary about They Might Be Giants |
| 41% | ABAA | 4 | Appropriate rhyme scheme for the last verse of They Might Be Giants' "Hate the Villanelle" |
| 40% | TRUECOLORS | 10 | Cyndi Lauper song with the lyric "So don't be afraid to let them show" |
| 39% | THETIDE | 7 | With 18-Across, Blondie #1 hit with the lyric "I'm gonna be your number one": 2 wds. |
| 39% | LIKEICAN | 8 | 46-Across song from the album "In the Lonely Hour" with the lyric "There may be lovers who hold out their hands, but / They'll never love you" (3 wds.) |
| 39% | POKEMONTHEME | 12 | Song with the lyrics "To catch them is my real test / to train them is my cause" |
| 38% | ARMS | 4 | The Hindu god Ganesha is often depicted with four of them |
| 38% | AXLES | 5 | Highway tolls may be based on the number of them |
| 38% | OGRES | 5 | They might be giants |
| 38% | BASEBALLPLAYERS | 15 | They Might Be Giants |
| 37% | BOSS | 4 | "___ of Me," 2001 song by They Might Be Giants and theme song of the family sitcom "Malcolm in the Middle" |
| 37% | USUALSUSPECTS | 13 | They may be rounded up after a crime, with "the" |
| 36% | LITERATURES | 11 | They may be studied along with languages |
| 36% | ABCS | 4 | "Here Come the ___" (They Might Be Giants album about learning the alphabet) |
| 36% | HONESTY | 7 | Billy Joel ballad with the lyrics "But if you look for truthfulness / You might just as well be blind" |
| 36% | FANGS | 5 | They might be a pain in the neck |
| 36% | FILES | 5 | They might be backed up in the cloud |
| 36% | SUNTANS | 7 | They might be brought back from the beach |
| 36% | STOOLS | 6 | They may be lined up at the bar |
| 36% | COTS | 4 | They may be folded up in the morning |
| 36% | BOSS | 4 | "___ of Me" (They Might Be Giants song featured on "Malcolm in the Middle") |
| 35% | COATS | 5 | They may be checked ... in two senses |
| 35% | PRESSURE | 8 | 24-Down single with the lyrics "But here you are in the ninth / Two men out and three men on / Nowhere to look but inside" |
| 35% | BEDS | 4 | They might be four-posters |
| 35% | SEEDS | 5 | They may be the pits |
| 35% | DUO | 3 | Rock's They Might Be Giants, e.g. |
| 35% | ALES | 4 | They may be pint-size with big heads |