| 100% | MYSTERIES | 9 | Things solved by Scooby-Doo and the gang |
| 47% | MYSTERY | 7 | Scooby and the gang's vehicle's name, __ machine |
| 42% | NAG | 3 | Annoy someone by asking the same thing again and again |
| 40% | INVADERS | 8 | "Scooby-Doo and the Alien ___" |
| 40% | KOOL | 4 | ___ and the Gang ("Celebration" band) |
| 40% | ISLA | 4 | Scooby Doo and Wedding Crashers actress Fisher |
| 39% | GREATDANE | 9 | Dog breed of Scooby-Doo and Astro from The Jetsons |
| 38% | COLLECTORSITEMS | 15 | Things gathered by aficionados ... or what the ends of 16-, 24-, 49- and 59-Across can be? |
| 37% | FRIENDSINHIGHPLACES | 19 | Rachel, Ross, and the gang climb the Himalayas? |
| 37% | SHAGGY | 6 | Scooby Doo's owner and best friend |
| 36% | THAT | 4 | This, ___, and the other thing |
| 36% | THIS | 4 | ___, that, and the other thing |
| 36% | STRANGER | 8 | "___ Things," sci-fi TV show created by The Duffer Brothers that was inspired by 21a, 25a, 43a, 2d, 38d and 43d |
| 36% | MISLED | 6 | Song title used by Kool & the Gang and Celine Dion |
| 35% | DAPHNE | 6 | Member of the Scooby-Doo gang |
| 35% | FRED | 4 | One of the Scooby-Doo gang |
| 35% | MAZE | 4 | Problem solved by the right-hand rule |
| 35% | JAMES | 5 | "___ and the Giant Peach," novel by Roald Dahl |
| 35% | SOFI | 4 | "___ and the Bone Song," novel by Adrienne Tooley |
| 35% | BENNIE | 6 | "___ and the Jets," 1973 song by Elton John |
| 35% | CHINESE | 7 | Like gunpowder and the seismometer, by origin |
| 35% | PACES | 5 | Things counted by the second? |
| 35% | ALES | 4 | Things sold by the yard? |
| 35% | LARGE | 5 | By and __; on the whole |
| 35% | LATENESS | 8 | Result of pushing things back, and what's spelled out by eight letters that have been literally pushed to the back |
| 35% | SHARKBAIT | 9 | Nickname given to Nemo by the Tank Gang |
| 35% | ANT | 3 | "The ___ and the Grasshopper" (fable by Aesop) |
| 34% | CASES | 5 | Things handled by stockers and doctors |
| 34% | VIBES | 5 | Things picked up by the perceptive |
| 34% | EGGS | 4 | Things usually sold by the dozen |