| 100% | ILOVEYOU | 8 | Thought expressed in American Sign Language by extending the pinkie, thumb and index finger |
| 37% | LOSER | 5 | Taunt indicated by an extended index finger and thumb by the forehead |
| 35% | ELL | 3 | Shape formed by an extended thumb and index fingers |
| 34% | ASL | 3 | Syst. in which making an "L" with the thumb and index finger and raising the pinkie means "I love you" |
| 33% | CUETIPS | 7 | "Cradle it between your thumb and index finger," and the like? |
| 32% | TEN | 3 | Shaken thumb, in American Sign Language |
| 31% | ELS | 3 | Shapes made by thumbs and index fingers |
| 29% | AND | 3 | Word usually indicated in charades by bringing the thumb close together with the index finger |
| 28% | AREA | 4 | "I was in the ___ and thought I'd drop by" |
| 28% | PINKY | 5 | What may represent "I" in American Sign Language |
| 28% | ESS | 3 | It's a fist in American Sign Language |
| 27% | PURLICUE | 8 | The space between the thumb and the index finger |
| 27% | YES | 3 | What a bobbing fist indicates in American Sign Language |
| 27% | BETTEMIDLER | 11 | American star of stage and screen celebrated by the Kennedy Center Honors in 2021 (2 wds.) |
| 27% | NADENE | 6 | Group of North American languages spoken in parts of Alaska, Canada and the southern US |
| 27% | CALLME | 6 | What an extended thumb and pinkie by your face might mean |
| 27% | CODA | 4 | Oscar-winning 2021 film with much dialogue in American Sign Language |
| 27% | CODA | 4 | Best Picture winner that includes much dialogue in American Sign Language |
| 26% | TERRY | 5 | "___ and the Pirates," adventure comic strip by Milton Caniff which follows a young American boy in China |
| 26% | EIGHT | 5 | Number indicated by touching the thumb to the middle finger, in ASL |
| 26% | LOSER | 5 | Insult signified by the thumb and pointer finger on one's forehead |
| 26% | OUTRAGE | 7 | "Fortitude: American Resilience in the Era of ___," 2020 memoir by politician and former Navy SEAL Dan Crenshaw |
| 26% | ASL | 3 | Sign language used in the United States |
| 25% | YES | 3 | What a fist bobbing up and down means in American Sign Language |
| 25% | ARMORYSHOW | 10 | The —, International Exhibition of Modern Art as organised by the Association of American Painters and Sculptors in New York in 1913 |
| 25% | ROCKON | 6 | Comment with the pinkie and forefinger extended upward |
| 24% | THUMBSCREW | 10 | Index, middle, ring and pinkie fingers? |
| 24% | CALLME | 6 | Gesture made with one’s thumb and pinkie extended |
| 24% | BODYMASS | 8 | The B and M in BMI, __ Index |
| 24% | SCORPIO | 7 | Sign of the zodiac in October and November |