| 100% | IRENE | 5 | Title character for Renee Zellweger in a 2000 comedy |
| 46% | RWANDA | 6 | Title character in a classic John Cleese comedy |
| 46% | BIGMOMMA | 8 | Title house owner in a 2000 Martin Lawrence comedy |
| 45% | JERRYMAGUIRE | 12 | 1996 film in which Renée Zellweger plays a single mom who falls for Tom Cruise's title character: 2 wds. |
| 43% | ROXIE | 5 | Actress Renee Zellweger's character in the 2002 musical crime comedy-drama "Chicago" |
| 42% | STARSKY | 7 | Title role for Stiller in a 2004 comedy |
| 40% | IRENE | 5 | Comedic title role for Renée Zellweger, 2000 |
| 39% | DRT | 3 | Sullivan Travis, in a 2000 film title |
| 38% | WHAT | 4 | "___ Women Want?" 2000 romantic comedy starring Mel Gibson and Helen Hunt, with a question in the title |
| 38% | AMAHL | 5 | Title character in a Menotti opera |
| 38% | BORIS | 5 | Title character in a Pushkin drama |
| 38% | HELEN | 5 | Title character in a Euripides drama |
| 38% | SONIC | 5 | Title character in a Sega game |
| 38% | ORFEO | 5 | Title character in a Gluck opera |
| 38% | AJAX | 4 | Title character in a Sophocles play |
| 38% | BORAT | 5 | Title character in a 2006 mockumentary |
| 38% | BEAST | 5 | Title character in a Disney film |
| 38% | RYAN | 4 | Title character in a Spielberg movie |
| 38% | LOLA | 4 | Title character in a Kinks song |
| 38% | MISSPOTTER | 10 | 2006 biopic starring Renee Zellweger in the title role |
| 38% | WARNER | 6 | David —, actor who played the title role in 1966 comedy-drama film Morgan: A Suitable Case for Treatment |
| 38% | CARRIE | 6 | Title character in a Theodore Dreiser novel |
| 38% | ALLIE | 5 | Title character in a 1980's sitcom |
| 38% | ABIE | 4 | Title character in a 1922 Broadway hit |
| 38% | MRKITE | 6 | Title character in a "Sgt. Pepper" song |
| 38% | ULEE | 4 | Title character in a 1997 bee movie |
| 38% | LORDJIM | 7 | Title character in a Joseph Conrad novel |
| 38% | OPPIE | 5 | Title character nickname in a 2023 blockbuster |
| 38% | APU | 3 | Title character in a Satyajit Ray trilogy |
| 37% | HATED | 5 | Word appearing three times in a 2000 Roger Ebert title |