| 100% | BUTCHCASSIDY | 12 | Title character in a classic western film who asks, "Who are those guys?" (2 wds.) |
| 51% | BUDABBOTT | 9 | Comedian in a classic sketch who is asked, "Who's on first?" (2 wds.) |
| 50% | MISSDAISY | 9 | Title character whom 15-Across chauffeured around in a 1989 film: 2 wds. |
| 49% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 49% | SETHMACFARLANE | 14 | "Family Guy" creator who wore a motion-capture suit to portray the title character in "Ted": 2 wds. |
| 48% | RICHARDCASTLE | 13 | Writer who was the title character in a 2009-2016 crime series: 2 wds. |
| 46% | JERRYMAGUIRE | 12 | 1996 film in which Renée Zellweger plays a single mom who falls for Tom Cruise's title character: 2 wds. |
| 46% | TIMOTHYDALTON | 13 | Actor from "Wuthering Heights", who has played James Bond in two films (as well as a third that was never released) : 2 wds. |
| 46% | NORMADESMOND | 12 | Character portrayed by actress Patti LuPone in the musical "Sunset Boulevard" which was based on a 1950 film of the same title: 2 wds. |
| 45% | CITIZENKANE | 11 | Classic 1941 film whose title character is partly based on William Randolph Hearst: 2 wds. |
| 43% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 43% | ROBINWILLIAMS | 13 | Actor who played Daniel Hillard, and the title character, in the 1993 film "Mrs. Doubtfire": 2 wds. |
| 42% | KEVINCOSTNER | 12 | "Field of Dreams" actor who starred as the title character in the 1990 film "Dances With Wolves": 2 wds. |
| 42% | EMMA | 4 | 1815 classic whose title character is played by Anya Taylor-Joy in a 2020 film |
| 42% | DONKEYKONG | 10 | Classic arcade game released by Nintendo in 1981 that features the adventures of a gorilla character: 2 wds. |
| 41% | IANMALCOLM | 10 | Actor Jeff Goldblum's character in 26a who is a mathematician and chaos theorist: 2 wds. |
| 41% | ALANRICKMAN | 11 | Actor who played Professor Snape and was a misunderstood character in "Harry Potter" series: 2 wds. |
| 41% | PIANOMAN | 8 | Person who was asked to "sing us a song tonight" in a Billy Joel hit: 2 wds. |
| 41% | RUNNINGSCARED | 13 | 1961 Roy Orbison hit that has the same title as, but is not featured in, a 1986 Gregory Hines/Billy Crystal film (2 wds.) |
| 41% | DAWSONSCREEK | 12 | Classic high-school drama series on the WB whose title character lives near a stream in Capeside, Massachusetts: 2 wds. |
| 41% | BLACKLIGHTNING | 14 | Superhero dad who was the title character on a show on a 2018-2021 CW show: 2 wds. |
| 41% | JAMESMCAVOY | 11 | "X-Men: Apocalypse" star who played the title character of 28-Across in a 2015 movie: 2 wds. |
| 40% | IROBOT | 6 | 1950 sci-fi fixup novel by Isaac Asimov that shares its title with a 2004 film starring Will Smith: 2 wds. |
| 40% | GUSTAVOFRING | 12 | Character played by Giancarlo Esposito in "Breaking Bad", who owns Los Pollos Hermanos, besides being a prominent meth distributor: 2 wds. |
| 40% | HENRYCAVILL | 11 | Actor known for playing a DC superhero who will be seen in the new "Mission: Impossible" film: 2 wds. |
| 40% | COSMOKRAMER | 11 | Character played by Michael Richards in "Seinfeld", who is 32-Across's neighbor and is often called a "hipster doofus": 2 wds. |
| 40% | THEMATRIX | 9 | A 1999 Sci-Fi film in which Keanu Reeves - whose birthday it is today - portrays the main character, named "Neo": 2 wds. |
| 40% | EWANMCGREGOR | 12 | Actor who plays the protagonist in "Christopher Robin" which is a fantasy film based on "Winnie-the-Pooh": 2 wds. |
| 40% | JOHNNYBRAVO | 11 | Muscular title character in a 1997-2004 Cartoon Network series: 2 wds. |
| 40% | OLDYELLER | 9 | Title stray dog in a 1957 Disney film: 2 wds. |