| 100% | MRPIM | 5 | Title character in an A. A. Milne play |
| 66% | AJAX | 4 | Title character in a Sophocles play |
| 64% | PIM | 3 | Title "Mr." in a Milne play |
| 64% | GODOT | 5 | Unseen title character in a Beckett play |
| 64% | GODOT | 5 | Unseen title character in a classic play |
| 61% | GODOT | 5 | Title character who never arrives in a Beckett play |
| 59% | ANDOR | 5 | Title character played by Diego Luna in a "Star Wars" TV series |
| 59% | CAMEO | 5 | Small character played by an A-lister in a film |
| 58% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 57% | MRPIM | 5 | A.A. Milne's play "___ Passes By" starring a title character with the first name of Carraway |
| 57% | ANDROCLES | 9 | Title character in an Aesop fable |
| 57% | AMELIE | 6 | Title character played by Audrey Tautou in a quirky 2002 Oscar-nominated French rom-com |
| 56% | YUBA | 4 | Rhyming title character who plays the tuba in Cuba, in a Rudy Vallee song |
| 56% | LACEY | 5 | Title character in an 80's police drama |
| 55% | EMMA | 4 | 1815 classic whose title character is played by Anya Taylor-Joy in a 2020 film |
| 55% | SULLENBERGER | 12 | Actor Tom Hanks's character in an eponymously titled biographical drama inspired by a real-life airline captain named Chesley ___ |
| 54% | ARCHIERICE | 10 | Title character in 1957 John Osborne stage play The Entertainer |
| 54% | GIGI | 4 | Precocious title character in an Oscar-winning film |
| 54% | JEDGARHOOVER | 12 | Real-life FBI director and title character played by Leonardo DiCaprio in a 2011 film: 3 wds. |
| 54% | SHEBA | 5 | Title dog in an Inge play |
| 54% | AMAHL | 5 | Title character in a Menotti opera |
| 54% | BORIS | 5 | Title character in a Pushkin drama |
| 54% | HELEN | 5 | Title character in a Euripides drama |
| 54% | SONIC | 5 | Title character in a Sega game |
| 54% | ORFEO | 5 | Title character in a Gluck opera |
| 54% | BORAT | 5 | Title character in a 2006 mockumentary |
| 54% | BEAST | 5 | Title character in a Disney film |
| 54% | RYAN | 4 | Title character in a Spielberg movie |
| 54% | LOLA | 4 | Title character in a Kinks song |
| 54% | JULIEANDREWS | 12 | Performer who won an Academy Award for Best Actress for playing the title character in her film debut, "Mary Poppins" (2 wds.) |