| 100% | PRIMEMINISTER | 13 | Title for 14- and 45-Across: 2 wds. |
| 58% | ELLIEGOULDING | 13 | 14-Across and 45-Across singer whose hit single "Love Me Like You Do" was nominated for a Grammy Award (2 wds.) |
| 53% | SIR | 3 | Title for 14 Across |
| 51% | WORLDCHAMPION | 13 | Eight-time title for 15-Across: 2 wds. |
| 49% | HERGRACE | 8 | Title for a duchess: 2 wds. |
| 49% | APEMAN | 6 | Title for Tarzan, with "the": 2 wds. |
| 48% | DUCHESSOF | 9 | With 35-Across, title for 15-Across: 2 wds. |
| 47% | FIRSTLADY | 9 | Title for Laura Bush or Michelle Obama: 2 wds. |
| 47% | ISABELSANFORD | 13 | Actress who played Louise on "All in the Family" and 45-Across (2 wds.) |
| 47% | MARVINGAYE | 10 | 14-Across and 45-Across singer who was inducted into the Rock and Roll Hall of Fame in 1987 (2 wds.) |
| 47% | DAME | 4 | Title for 17-Across, 22-Across,
37-Across, 45-Across, and 57-Across, in addition to "Academy Award Winner" |
| 46% | DANCEMONKEY | 11 | 2019 hit for Tones and I with a sign of the Chinese zodiac in its title: 2 wds. |
| 46% | IMREAL | 6 | 2001 #1 song for 45-Across (2 wds.) |
| 45% | MYWAY | 5 | Song title for Frank Sinatra or Fetty Wap: 2 wds. |
| 45% | GORDONRAMSAY | 12 | British celebrity chef known for his temper who hosts 14-Across and 26-Across (2 wds.) |
| 45% | NBAALLSTAR | 10 | Title for 46-Across 12 consecutive times from 1961 to 1972 (2 wds.) |
| 45% | IRONCHEF | 8 | Food Network title for Bobby Flay or Mario Batali: 2 wds. |
| 44% | SPARETIME | 9 | Leisure period for hobbies and such: 2 wds. |
| 44% | DOGFOOD | 7 | Canned stuff for poodles and beagles: 2 wds. |
| 43% | SIR | 3 | Title for 48-Across and 3-Down |
| 43% | ANNAQUINDLEN | 12 | "One True Thing," 14-Across, and 26-Across/29-Across novelist who won the Pulitzer Prize for Commentary in 1992 (2 wds.) |
| 43% | BUGSBUNNY | 9 | Looney Tunes character pursued by 28-Across and 45-Across (2 wds.) |
| 42% | ABOUTME | 7 | Title for a blog's biographical section (2 wds.) |
| 42% | KEVINHART | 9 | "Ride Along" actor/comedian who co-stars with Tiffany Haddish and 45-Across in 29-Across (2 wds.) |
| 42% | WASHTUBS | 8 | Large buckets for soaking and cleaning clothes: 2 wds. |
| 42% | DCCOMICS | 8 | Publisher known for Flash and Green Lantern: 2 wds. |
| 41% | COMEDYCENTRAL | 13 | Network for 15-Across and 20-Across: 2 wds. |
| 41% | KELLYCLARKSON | 13 | 16-Across and 45-Across singer who won the first season of "American Idol" (2 wds.) |
| 41% | PULITZERPRIZE | 13 | Award that 14-Across won twice, for "Fences" and "The Piano Lesson": 2 wds. |
| 41% | DOLLARBABY | 10 | See 45-Across: 2 wds. |