| 100% | BILKO | 5 | Title sergeant played by Steve Martin in a 1996 comedy |
| 51% | CHARLIEWILSON | 13 | Title role played by Tom Hanks in a 2007 comedy-drama: 2 wds. |
| 50% | LARRYCROWNE | 11 | Title role played by Tom Hanks in a 2011 romantic comedy: 2 wds. |
| 48% | KAZAAM | 6 | Title genie played by Shaquille O'Neal in a 1996 film |
| 43% | AMELIA | 6 | Title role played by Hilary Swank in a 2009 biopic |
| 43% | LILO | 4 | Title role played by Maia Kealoha in a 2025 remake |
| 42% | VIWARSHAWSKI | 12 | Title detective played by Kathleen Turner in a 1991 film: 3 wds. |
| 42% | MARIEANTOINETTE | 15 | Title queen played by Kirsten Dunst in a 2006 Sofia Coppola film |
| 42% | ANDOR | 5 | Title character played by Diego Luna in a "Star Wars" TV series |
| 41% | THEGRINCH | 9 | Title villain played by Jim Carrey in a 2000 Christmas movie (2 wds.) |
| 41% | FORRESTGUMP | 11 | Title role played by Tom Hanks in a 1994 Oscar-winning movie: 2 wds. |
| 41% | AMELIE | 6 | Title character played by Audrey Tautou in a quirky 2002 Oscar-nominated French rom-com |
| 40% | BABE | 4 | Title animal played by 48 different pigs in a 1995 movie |
| 40% | PABLOPICASSO | 12 | Spanish artist played by Anthony Hopkins in a 1996 biopic (2 wds.) |
| 38% | KILLERJOE | 9 | Title hit man played by Matthew McConaughey in a 2011 film |
| 38% | BANJO | 5 | Instrument played by Steve Martin |
| 38% | BANJO | 5 | Stringed instrument played by Steve Martin |
| 38% | HAPPYGILMORE | 12 | 1996 sports comedy in which 29-Across played the title role: 2 wds. |
| 37% | ALFIE | 5 | Michael Caine 1966 title role played by Jude Law in a 2004 remake |
| 37% | BIGMOMMA | 8 | Title house owner in a 2000 Martin Lawrence comedy |
| 37% | DAVIDSTARSKY | 12 | Character played by Ben Stiller in a 2004 comedy-crime film co-starring Owen Wilson as Ken Hutchinson |
| 37% | THEBIRDCAGE | 11 | 1996 film comedy in which Dianne Wiest played a conservative senator's wife: 2 wds. |
| 36% | EMMA | 4 | Jane Austen title heroine played by Anya Taylor-Joy in a 2020 film adaptation |
| 36% | GHOSTWORLD | 10 | 2001 black comedy in which Steve Buscemi plays a lonely man named Seymour: 2 wds. |
| 35% | GRANDBUDAPEST | 13 | A 2014 comedy film "The ___ Hotel" by Wes Anderson in which actress from 18a plays a chef: 2 wds. |
| 34% | THEOFFICE | 9 | A comedy which starred Steve Carell as Michael Scott, in which 17-Across played his rival, Charles Miner: 2 wds. |
| 34% | CANDIDA | 7 | Comedy play written by George Bernard Shaw in 1894 that revolves around the lives of a clergyman and his wife |
| 34% | JERRYMAGUIRE | 12 | 1996 film in which Renée Zellweger plays a single mom who falls for Tom Cruise's title character: 2 wds. |
| 34% | WARNER | 6 | David —, actor who played the title role in 1966 comedy-drama film Morgan: A Suitable Case for Treatment |
| 34% | DENTIST | 7 | Steve Martin played a sadistic singing one |