| 100% | ANDREAMCARDLE | 13 | Tony-nominated actress who was the first to play 40-Across on Broadway (2 wds.) |
| 53% | AMELIAEARHART | 13 | Aviation pioneer who was the first woman to fly solo across the Atlantic: 2 wds. |
| 53% | RUBYROSE | 8 | "Orange Is the New Black" actress who plays Kate Kane on 14-Across: 2 wds. |
| 53% | NAOMICAMPBELL | 13 | "American Horror Story: Hotel" actress who was the first black model on the cover of French Vogue : 2 wds. |
| 52% | ETHELWATERS | 11 | Harlem Renaissance singer and actress who was the first African American to star in her own TV show: 2 wds. |
| 51% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 51% | JOSECANSECO | 11 | Retired ballplayer who was the first to hit 40 homers and steal 40 bases in the same season: 2 wds. |
| 50% | BENNYGOODMAN | 12 | Big Band bandleader who was the first jazz bandleader to play Carnegie Hall (2 wds.) |
| 50% | DEE | 3 | Actress Sandra who was the first to play Gidget |
| 50% | DEE | 3 | Actress Sandra who was the first to play "Gidget" |
| 50% | CANDICEBERGEN | 13 | Actress who was the first woman to host "Saturday Night Live," and the first woman to host five times (2 wds.) |
| 49% | ANNAFARIS | 9 | Actress who played Christy Plunkett on the first seven seasons of the CBS sitcom "Mom": 2 wds. |
| 49% | LETITIAWRIGHT | 13 | Actress who plays Shuri in the Marvel Cinematic Universe and has been on "Black Mirror": 2 wds. |
| 49% | KARYNPARSONS | 12 | Actress who played the snobbish cousin of 17-Across in "The Fresh Prince of Bel-Air," which is rumored to be getting a reunion: 2 wds. |
| 49% | HILARYSWANK | 11 | "Amelia" actress who plays an astronaut heading to Mars on the Netflix series "Away": 2 wds. |
| 49% | LAURAPREPON | 11 | "Orange Is the New Black" actress who played Donna Pinciotti on "That '70s Show": 2 wds. |
| 48% | GINARODRIGUEZ | 13 | Actress who plays the title role on 15-Across: 2 wds. |
| 48% | GEOFFREYRUSH | 12 | "Shine" star who was the first Australian to be nominated for Oscars in two acting categories (2 wds.) |
| 48% | STEPHENSTILLS | 13 | American singer and songwriter who is the first artist to be inducted twice on the same night into the Rock and Roll Hall of Fame: 2 wds. |
| 48% | JENNADEWAN | 10 | "Step Up" actress who was the first host of "World of Dance": 2 wds. |
| 48% | CANDICEBERGEN | 13 | Actress who was the first female host of "Saturday Night Live": 2 wds. |
| 48% | NICOLEKIDMAN | 12 | "Moulin Rouge!" and "The Hours" star who was the first Australian to win an Oscar for Best Actress and the first to be nominated in consecutive years (2 wds.) |
| 48% | RUBYROSE | 8 | "Orange Is the New Black" actress who played Bruce Wayne's cousin Kate Kane on 44-Across (2 wds.) |
| 48% | LUCYLIU | 7 | Actress who played Joan (based on 47-Across) on the CBS series "Elementary": 2 wds. |
| 48% | EMILYMORTIMER | 13 | Actress who plays MacKenzie McHale, the executive producer on 37-Across: 2 wds. |
| 48% | EMMATHOMPSON | 12 | Actress who plays the protagonist in "Nanny McPhee and the Big Bang," which is based on the "Nurse Matilda" books: 2 wds. |
| 48% | SALONGA | 7 | Lea who was the first Asian actress to win a Tony |
| 47% | TORISPELLING | 12 | Actress who was the Unicorn on season 1 of "The Masked Singer": 2 wds. |
| 47% | AUDRAMCDONALD | 13 | Six-time Tony-winning actress who was a guest on the "On Broadway" episode of "Finding Your Roots" in 2021 (2 wds.) |
| 47% | HALLEBERRY | 10 | "Swordfish" actress who was the first runner-up in the Miss USA pageant in 1986: 2 wds. |