| 100% | PETERCAPALDI | 12 | Twelfth actor to play the lead role in 15-Across, starting in 2013: 2 wds. |
| 77% | MATTSMITH | 9 | Eleventh actor to play the lead role in 15-Across (2010-2013): 2 wds. |
| 74% | DAVIDTENNANT | 12 | Tenth actor to play the lead role in 15-Across (2005-2010): 2 wds. |
| 56% | MARKWAHLBERG | 12 | Actor from "The Italian Job", who plays the lead role of Cade Yeager in 30-Across : 2 wds. |
| 54% | RODDYPIPER | 10 | Rowdy ___, a wrestler who went on to play the lead role in the cult classic "They Live": 2 wds. |
| 53% | DENNISQUAID | 11 | "Flight of the Phoenix" actor who plays the title role in 16-Across: 2 wds. |
| 53% | BOBODENKIRK | 11 | "Breaking Bad" actor who plays the lead role on 33-Across: 2 wds. |
| 53% | TONYTODD | 8 | "Final Destination" actor who plays the title role in 16-Across: 2 wds. |
| 52% | EDDIEMURPHY | 11 | "Coming to America" actor who played the title role in 1998's "Dr. Dolittle": 2 wds. |
| 52% | HENRYFONDA | 10 | "On Golden Pond" actor who played the title role in 32-Across: 2 wds. |
| 51% | ELLIEKEMPER | 11 | Actress who plays the lead role in 12-/24-Across: 2 wds. |
| 50% | KITHARINGTON | 12 | "Pompeii" lead actor, who plays the role of Jon Snow in "Game Of Thrones" : 2 wds. |
| 48% | TOMELLIS | 8 | Actor who plays the titular role in the fantasy series "Lucifer": 2 wds. |
| 48% | MICHAELKEATON | 13 | "Mr. Mom" actor who played the title role in 40-Across (2 wds.) |
| 48% | MATTHEWRHYS | 11 | "The Americans" actor who plays the title role in HBO's "Perry Mason": 2 wds. |
| 47% | EWANMCGREGOR | 12 | "Beauty and the Beast" actor who plays the title role in the new movie "Christopher Robin": 2 wds. |
| 46% | MELGIBSON | 9 | "Lethal Weapon" and "Braveheart" actor who turned down the lead role in "Gladiator": 2 wds. |
| 46% | GINARODRIGUEZ | 13 | Actress who plays the title role on 15-Across: 2 wds. |
| 46% | VITOCORLEONE | 12 | Character who has the title role in 15-Across: 2 wds. |
| 45% | SWANLAKE | 8 | Tchaikovsky dance classic in which 15-Across performed the lead role of Odette/Odile: 2 wds. |
| 45% | TOMHARDY | 8 | "The Dark Knight Rises" actor who plays "Mad" Max Rockatansky in 15-Across: 2 wds. |
| 45% | MADSMIKKELSEN | 13 | "Hannibal" actor who plays the villain Kaecilius in 32-Across: 2 wds. |
| 45% | JASONROBARDS | 12 | Actor who played 15-Across in the 1967 film "The St. Valentine's Day Massacre": 2 wds. |
| 45% | MELGIBSON | 9 | Actor who played the lead character, "Mad" Max Rockatansky in the 1979 film "Mad Max": 2 wds. |
| 45% | TARONEGERTON | 12 | "Rocketman" actor who plays the title role in the 2018 film "Robin Hood" (2 wds.) |
| 45% | RUSSELLCROWE | 12 | "Gladiator" actor who plays the title role in the 2010 film "Robin Hood" (2 wds.) |
| 45% | TARONEGERTON | 12 | "Kingsman: The Golden Circle" actor who plays the title character in 16-Across: 2 wds. |
| 45% | JULIEANDREWS | 12 | Actress who won an Oscar for playing the title role in 39-Across: 2 wds. |
| 45% | CHRISEVANS | 10 | "Avengers: Endgame" actor who plays a cult leader in 15-Across: 2 wds. |
| 45% | ALECBALDWIN | 11 | Actor who made a cameo in "Glengarry Glen Ross" by playing the role of Blake, the guy who is sent to motivate the sales team: 2 wds. |