| 100% | ORTHRUS | 7 | Two-headed dog, the brother of Cerberus |
| 56% | DOS | 3 | Heading for the first of two columns |
| 53% | SIRIUS | 6 | The dog star, the head of Canis Major |
| 52% | ODIE | 4 | Dog in the movie "Garfield: A Tail of Two Kitties" |
| 51% | AMA | 3 | Org. once headed by each of the Mayo brothers |
| 51% | EARS | 4 | Two on the side of the head |
| 49% | COCKATRICE | 10 | Mythical creature; a two-legged dragon with the head of a cockerel |
| 49% | HARPER | 6 | Surname of the brothers in Two and a Half Men |
| 48% | STEVENASH | 9 | Two-time NBA MVP who became head coach of the Nets in 2020: 2 wds. |
| 47% | AAR | 3 | ___on, the brother of Moses |
| 46% | JOSEF | 5 | Composer Strauss, the brother of Johann |
| 46% | ABEL | 4 | The brother of "Am I my brother's keeper?" |
| 46% | KINGJOHN | 8 | English monarch, the brother of King Richard |
| 46% | HAKE | 4 | Food fish of the northern hemisphere with an elongated body, large head and two dorsal fins |
| 46% | THEBURGESSBOYS | 14 | Elizabeth Strout novel set in the fictional town of Shirley Falls about two brothers (3 wds.) |
| 46% | EARP | 4 | Brother of the Wild West |
| 46% | STPETER | 7 | Brother of Andrew the Apostle |
| 45% | EARPS | 5 | Brothers of the Wild West |
| 45% | RIC | 3 | Documentarian Burns who's the brother of Ken |
| 45% | ABSALOM | 7 | Brother of Tamar, in the Bible |
| 45% | LABAN | 5 | Brother of Rebecca, in the Bible |
| 45% | ABEL | 4 | Brother of Cain, in the bible |
| 45% | CAIN | 4 | Brother of Seth, in the Bible |
| 44% | MOE | 3 | Stooge who was the brother of Curly and Shemp |
| 44% | ALVIN | 5 | Brother of the chipmunks Simon and Theodore |
| 44% | ROB | 3 | Youngest brother of the Kardashians |
| 43% | REESE | 5 | Brother of Malcolm on "Malcolm in the Middle" |
| 43% | ELI | 3 | Brother of the N.F.L.’s Peyton |
| 43% | BAERS | 5 | Ring brothers of the 1930's |
| 43% | MAHRES | 6 | Skiing brothers of the 1984 Olympics |