| 100% | DIAMONDJIMBRADY | 15 | Tycoon who was the first person in New York City to own a car |
| 75% | DIAMONDJIMBRADY | 15 | Tycoon who was reputedly the first person in New York City to own an automobile |
| 48% | ANGELA | 6 | Bassett who was the first person to be nominated for an Oscar for acting in a Marvel movie |
| 45% | YUTOHORIGOME | 12 | Japanese skateboarder who was the first person to win a gold medal in skateboarding at the Olympics, in men's street skateboarding in Tokyo in 2021 (2 wds.) |
| 44% | ULRIC | 5 | German prelate who was the first person to be canonized, A.D. 993 |
| 43% | OMAR | 4 | Ilhan who was the first person to wear a hijab on the House floor |
| 43% | ALTHEA | 6 | Gibson who was the first person of color to win a tennis Grand Slam event |
| 43% | ALTHEAGIBSON | 12 | Tennis great who was the first person of color to win a Wimbledon championship (2 wds.) |
| 42% | TYUS | 4 | Wyomia ___, former American sprinter who was the first person to retain the Olympic title in the 100 m |
| 42% | ITO | 3 | Olympic skater who was the first woman to land a triple axel in competition |
| 42% | ITO | 3 | Skater Midori who was the first woman to land a triple axel in competition |
| 42% | REBA | 4 | McEntire who is the first woman to portray Colonel Sanders in a KFC ad |
| 42% | STEVE | 5 | Fossett, who was the first person to fly around the world alone, in 1995, covering 20,482.26 miles |
| 41% | FREEMAN | 7 | Cathy ___, sprinter who was the first Australian indigenous person to become a Commonwealth Games gold medalist |
| 41% | BLACKWELL | 9 | Elizabeth ___, British physician who was the first woman to earn a medical degree in the US |
| 41% | BARRY | 5 | ___ Nelson, American actor who was the first to portray James Bond in a television series titled "Climax!" |
| 41% | RYUN | 4 | Jim ___, athlete who was the first high school junior to run a mile in under four minutes |
| 41% | YURI | 4 | Cosmonaut Gagarin who was the first person in space |
| 41% | THEJEFFERSONS | 13 | Sitcom set in New York city that was a spin-off of "All in the Family" (2 wds.) |
| 41% | LEE | 3 | Rebecca ___ Crumpler, physician who was the first African-American woman in the US to earn a medical degree |
| 41% | LISALESLIE | 10 | Basketball Hall of Fame inductee who was the first player to dunk in a WNBA game: 2 wds. |
| 40% | ETHELWATERS | 11 | Harlem Renaissance singer and actress who was the first African American to star in her own TV show: 2 wds. |
| 40% | RUDOLPH | 7 | Wilma ___, late American sprinter who was the first American woman to win three gold medals in a single Olympic Games |
| 39% | LISALESLIE | 10 | L.A. Sparks player who was the first to dunk in a W.N.B.A. game |
| 39% | CURIE | 5 | Marie who is the only person to win a Nobel Prize in two different science fields |
| 39% | WAYNEGRETZKY | 12 | Hockey legend who was the first since Bobby Orr to tally 100+ assists in a season, and did so 11 times: 2 wds. |
| 39% | LETITIAJAMES | 12 | New York attorney general who filed a lawsuit in August, 2020, to dissolve the N.R.A. |
| 39% | MARIE | 5 | Curie who was the first person to win two Nobel Prizes |
| 38% | ROME | 4 | First city to reach a population of one million people, in the second century B.C. |
| 38% | GWENJORGENSEN | 13 | American distance runner and two-time ITU World Champion who was the first to win a triathlon gold for USA in the Olympics: 2 wds. |