| 100% | CAPONE | 6 | U.S.'s first so-called "Public Enemy No. 1" |
| 56% | CAIN | 4 | Public enemy No. 1? |
| 55% | FLOYD | 5 | Public enemy No. 1, 1933 |
| 48% | ANNEMURRAY | 10 | First Canadian female solo artist to reach No. 1 on the U.S. Billboard Hot 100 |
| 45% | APPLE | 5 | First public U.S. company to be valued at $1 trillion |
| 42% | RITAORA | 7 | Pop star whose first U.K. No. 1 hit was “How We Do (Party)” |
| 41% | SOS | 3 | Rihanna’s first No. 1 single |
| 39% | CARUSO | 6 | Performer in the first U.S. public radio broadcast, 1910 |
| 39% | GENIE | 5 | "___ in a Bottle" (Christina Aguilera's first No. 1 song) |
| 38% | HST | 3 | He called the U.S. pres. a "glorified public relations man" |
| 38% | OSLIN | 5 | K.T. with four No. 1 hits in the U.S. |
| 38% | HIRAM | 5 | U. S. Grant's given first name |
| 36% | ABBA | 4 | Alphabetically first pop group with a No. 1 hit |
| 36% | OREM | 4 | So-called Family City U.S.A. |
| 36% | JOHNDILLINGER | 13 | Depression-era gangster who was the FBI's first "Public Enemy #1": 2 wds. |
| 36% | WATERMELONSUGAR | 15 | Harry Styles’s first No. 1 single on the Billboard Hot 100 (August, 2020) |
| 36% | BIEBER | 6 | Singer Justin whose first No. 1 hit was 2015's "What Do You Mean?" |
| 36% | MOBY | 4 | US musician born Richard Melville Hall who recorded no 1 albums Play and 18 |
| 35% | THANKU | 6 | “___, Next” (20-Across’s first No. 1 single and the title of her 2019 album) |
| 35% | ASHANTI | 7 | Her 2002 self-titled album debuted at No. 1 on the U.S. Billboard 200 |
| 35% | TBS | 3 | First so-called "superstation" |
| 35% | RAYON | 5 | So-called "laboratory's first gift to the loom" |
| 35% | WHISTLER | 8 | James McNeill —, US artist whose works include Arrangement in Grey and Black, No 1: The Artist's Mother |
| 35% | DAVENPORT | 9 | Lindsay __, former US no. 1 tennis player |
| 35% | ENRICO | 6 | Caruso who was featured on the first public-radio broadcast in the U.S., in 1910 |
| 35% | HEART | 5 | "___ of Gold," 1972 song by Neil Young which is his only U.S. No. 1 single |
| 34% | LOEB | 4 | First unsigned artist to record a Billboard No. 1 hit |
| 34% | APPLE | 5 | First U.S. company to be valued at $1 trillion |
| 34% | LOLLIPOP | 8 | My Boy __, first ska no. 1, for Millie |
| 34% | BABEL | 5 | Mumford & Sons album that debuted at No. 1 on the U.S. Billboard 200 in 2012 |