| 100% | RONALDREAGAN | 12 | U.S. president who was the first born in Illinois, the first to have been divorced, and the first to nominate a woman to the Supreme Court (2 wds.) |
| 51% | WARRENHARDING | 13 | U.S. president who was the first to be elected on his birthday, the first born after the Civil War, and the first elected after women gained the right to vote (2 wds.) |
| 50% | JAMESMADISON | 12 | U.S. president who was the first to have served in the House of Representatives, the first to have an inaugural ball, and the first to wear long pants instead of knee breeches (2 wds.) |
| 44% | SHOHEIOHTANI | 12 | Japanese MLB player who was the first player in history to be a pitcher and hitter in the All-Star Game, in 2021: 2 wds. |
| 43% | JACKIESTILES | 12 | 2016 Women's Basketball Hall of Fame inductee who was the first Division I player to score over 1,000 points in a season: 2 wds. |
| 43% | TONIMORRISON | 12 | "Beloved" author who died August 5, and who was the first African-American woman to win a Nobel Prize: 2 wds. |
| 43% | EDITHWHARTON | 12 | 13-Across and 25-Across writer who was the first woman to win a Pulitzer Prize in Literature, for her 1920 novel "The Age of Innocence" (2 wds.) |
| 42% | WAYNEGRETZKY | 12 | Hockey legend who was the first since Bobby Orr to tally 100+ assists in a season, and did so 11 times: 2 wds. |
| 41% | STEFFIGRAF | 10 | Tennis player who is the only player (man or woman) to win a Grand Slam and Olympic gold medal in one year: 2 wds. |
| 41% | GWENJORGENSEN | 13 | American distance runner and two-time ITU World Champion who was the first to win a triathlon gold for USA in the Olympics: 2 wds. |
| 41% | GRETATHUNBERG | 13 | First Swedish woman and first person born in the 21st century to be named "Time" magazine's Person of the Year (2 wds.) |
| 41% | WARRENGHARDING | 14 | U.S. president who, in 1922, became the first president to have his voice transmitted on the radio (3 wds.) |
| 41% | LORNASIMPSON | 12 | "Projects 23" photographer who was the first African-American woman to have a solo exhibition at the Museum of Modern Art (2 wds.) |
| 40% | KAMALAHARRIS | 12 | Former California senator who is the first woman and first person of color to be inaugurated as vice president of the United States (2 wds.) |
| 39% | MARGARETCOURT | 13 | Australian tennis player who was the first woman to win the Grand Slam in the Open Era: 2 wds. |
| 39% | EVELYNASHFORD | 13 | The first track and field athlete to run 100 meters under 11 seconds in an Olympic Games and who has won a total of 5 Olympic medals: 2 wds. |
| 39% | BLACKWELL | 9 | Elizabeth ___, British physician who was the first woman to earn a medical degree in the US |
| 39% | LEE | 3 | Rebecca ___ Crumpler, physician who was the first African-American woman in the US to earn a medical degree |
| 39% | LISALESLIE | 10 | Basketball Hall of Fame inductee who was the first player to dunk in a WNBA game: 2 wds. |
| 38% | IGGYAZALEA | 10 | "Fancy" singer who is one of only two music acts to have their first two hit singles rank #1 and #2 simultaneously on the U.S. "Billboard" Hot 100 chart (2 wds.) |
| 38% | SEATTLESLEW | 11 | 1977 Triple Crown winner who was the first American champion to have been undefeated in previous races: 2 wds. |
| 38% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 38% | ANNPRESTON | 10 | American physician and activist who was the first female dean of a medical school in the world: 2 wds. |
| 38% | BARACKOBAMA | 11 | U.S. president who has been listed on the TIME 100 a record 11 times (2 wds.) |
| 38% | JOSECANSECO | 11 | Retired ballplayer who was the first to hit 40 homers and steal 40 bases in the same season: 2 wds. |
| 38% | ETHELWATERS | 11 | Harlem Renaissance singer and actress who was the first African American to star in her own TV show: 2 wds. |
| 38% | NICOLEKIDMAN | 12 | "Moulin Rouge!" and "The Hours" star who was the first Australian to win an Oscar for Best Actress and the first to be nominated in consecutive years (2 wds.) |
| 38% | TAMMYDUCKWORTH | 14 | Illinois congresswoman and Iraq War veteran elected to her first term as a US senator in 2016: 2 wds. |
| 37% | TIMDUNCAN | 9 | Spurs power forward for 19 years, who was a top U.S. swimmer in the 400m freestyle before shifting to basketball: 2 wds. |
| 37% | YUTOHORIGOME | 12 | Japanese skateboarder who was the first person to win a gold medal in skateboarding at the Olympics, in men's street skateboarding in Tokyo in 2021 (2 wds.) |