| 100% | POWELL | 6 | U.S. secretary of state raised in the Bronx |
| 65% | DEANRUSK | 8 | U.S. secretary of state tied for the second-longest time in office |
| 54% | CITY | 4 | Word in the names of four U.S. state capitals |
| 54% | CITY | 4 | Last word in the names of four U.S. state capitals |
| 51% | EAST | 4 | Only cardinal direction that does not appear in the name of a U.S. state |
| 51% | TULSA | 5 | City in the US state of Oklahoma |
| 51% | THEMONROEDOCTRINE | 17 | John Quincy Adams, as U.S. secretary of state, was the man who actually drafted … |
| 50% | PORTLAND | 8 | Biggest city in the US state of Maine |
| 50% | ILIAMNA | 7 | — Lake, largest in the US state of Alaska |
| 50% | DAKOTA | 6 | Word in the names of two US states |
| 50% | TENTH | 5 | Like the secretary of commerce, in the U.S. presidential line of succession |
| 50% | CHICAGO | 7 | Most populated city in the US state of Illinois |
| 50% | ALEXANDERHAIG | 13 | Secretary of State who suggested a "nuclear warning shot" in Europe would deter the Soviet Union |
| 49% | REXTILLERSON | 12 | The current US Secretary of State: 2 wds. |
| 49% | RAINIER | 7 | Mount —, volcano and highest mountain in the state of Washington, US |
| 49% | SDAK | 4 | Only U.S. state in which the name of the state and its capital share no letters: Abbr. |
| 48% | JAMESMADISON | 12 | US Secretary of State (and fourth president) who oversaw the Louisiana Purchase: 2 wds. |
| 48% | MEXICO | 6 | US state with the name of country in it, New __ |
| 48% | GEORGESCHULTZ | 13 | Secretary of State who was in office when the Intermediate Range Nuclear Forces Treaty was signed with Mikhail Gorbachev |
| 48% | KERRY | 5 | John —, US Secretary of State appointed in 2003 |
| 48% | CAR | 3 | One of 52 million in the U. S. |
| 48% | EAST | 4 | Only cardinal direction that’s not in the name of a U.S. state |
| 47% | ALBRIGHT | 8 | First female U.S. secretary of state |
| 47% | ALB | 3 | First female U.S. secretary of state |
| 46% | BUFFALO | 7 | US port in New York State at the eastern end of Lake Erie |
| 46% | ALEXANDERHAIG | 13 | US Secretary of State who announced "I am in control here" after President Reagan was shot: 2 wds. |
| 46% | URI | 3 | School in the smallest U.S. state |
| 46% | URI | 3 | Sch. in the smallest U.S. state |
| 46% | DANIELWEBSTER | 13 | Secretary of State in 1851 |
| 46% | SKUNK | 5 | Florida ___ Ape, mysterious semi-human cryptid said to dwell in the swamps of southeastern US states |