| 100% | DRAWTWO | 7 | Uno card that causes the next player to take more cards and lose a turn (2 wds.) |
| 61% | SKIP | 4 | Uno card that causes the next player to miss a turn |
| 53% | SKIP | 4 | UNO card that makes the next player lose a turn |
| 50% | SKIP | 4 | Uno card that causes a player to lose a turn |
| 48% | SKIP | 4 | Uno card that makes the next player miss a turn |
| 47% | DRAW | 4 | ___ two, play this card to make the next player take two cards and lose their turn |
| 46% | SKIP | 4 | 24-Down card that makes the next player lose a turn |
| 46% | SKIP | 4 | 55-Down card that makes the next player lose a turn |
| 43% | WILD | 4 | Uno card that lets a player declare the next color to be played |
| 43% | WILD | 4 | Uno card that lets a player decide the next color to be played |
| 43% | WILD | 4 | Uno card that lets a player decide the next color to be matched |
| 36% | DEALOUT | 7 | Omit a player from those to whom cards are dealt: 2 wds. |
| 34% | ALEXRODRIGUEZ | 13 | Mariners shortstop who, in 1998, became the youngest player to that point to hit 40 homers and steal 40 bases: 2 wds. |
| 33% | MOUSELEMUR | 10 | A species unique to Madagascar that is the world's smallest primate and one of the smallest mammals in the world: 2 wds. |
| 33% | STEFFIGRAF | 10 | Tennis player who is the only player (man or woman) to win a Grand Slam and Olympic gold medal in one year: 2 wds. |
| 33% | SKIP | 4 | Play this card when you want the next player to miss their turn |
| 33% | SWEETDAY | 8 | "One ___," a song by Mariah Carey and Boyz II Men, that was Billboard's most successful song of the 1990s: 2 wds. |
| 33% | LIGHTBULB | 9 | Notable invention from the 19th century, that brought steady light to households, and stands as a symbol of an idea: 2 wds. |
| 33% | ETAL | 4 | Phrase similar to "etc." that is added at the end of a list to mean that there are more unlisted items: 2 wds. |
| 33% | BEOUR | 5 | With 35-Across, Oscar-nominated song from Disney's "Beauty and the Beast" that lost to that movie's title song: 2 wds. |
| 33% | ANGELSHARK | 10 | One of the rarest creatures, that looks more like a Manta Ray than a Great White, now critically endangered due to fishing: 2 wds. |
| 32% | ACE | 3 | Card that loses to a 2 in some games |
| 32% | SHOHEIOHTANI | 12 | Japanese MLB player who was the first player in history to be a pitcher and hitter in the All-Star Game, in 2021: 2 wds. |
| 32% | BLANKSPACE | 10 | Second single from Taylor Swift's fifth album, that received three Grammy nominations, and had a part in the lyrics misheard by many: 2 wds. |
| 31% | LBOMB | 5 | Word that takes a relationship to the next level, slangily |
| 31% | NOTSPAM | 7 | Button that moves a message to the inbox: 2 wds. |
| 31% | FRANKROBINSON | 13 | Most Valuable Player in both the AL (Orioles, 1966) and NL (Reds, 1961): 2 wds. |
| 31% | MARIOLEMIEUX | 12 | Penguins center who was the third player to have a 100-assist season: 2 wds. |
| 31% | SCOTTIEPIPPEN | 13 | Player tied with 15-Across for the most NBA championships with a single team that isn't the 32-Across (2 wds.) |
| 31% | LSUTIGERS | 9 | Team that beat the Iowa Hawkeyes to win 2023 NCAA women's basketball championship, led by NCAA Tournament Most Outstanding Player Angel Reese (2 wds.) |