| 100% | WILLIAMMONK | 11 | Victorian inspector in a mystery series by novelist Anne Perry (2 wds.) |
| 80% | THEPITTFAMILY | 13 | Household of Victorian investigators in a mystery series by novelist Anne Perry (3 wds.) |
| 70% | ELENASTANDISH | 13 | Photographer in a post-WWI mystery series by novelist Anne Perry (2 wds.) |
| 54% | ARMANDGAMACHE | 13 | Chief inspector in a series of mystery novels by Louise Penny (2 wds.) |
| 47% | ARMANDGAMACHE | 13 | Québec Chief Inspector in the mystery series by 40-Across (2 wds.) |
| 41% | TWINPEAKS | 9 | Mystery series starring Kyle MacLachlan that's named for a fictional town in Washington: 2 wds. |
| 41% | ONE | 3 | "___ for the Money" (first in a mystery series by Janet Evanovich) |
| 40% | AUNT | 4 | "___ Dimity's Death" (first volume in a mystery series by Nancy Atherton) |
| 39% | EVEDUNCAN | 9 | Forensic sculptor in a series of novels by Iris Johansen (2 wds.) |
| 39% | LADIES | 6 | "The No. 1 ___ Detective Agency" (first novel in a mystery series by Alexander McCall Smith) |
| 38% | TESSMONAGHAN | 12 | Reporter-turned-investigator in a series of novels by 44-Across (2 wds.) |
| 38% | VIRGINRIVER | 11 | Romance series by Robyn Carr set in a California mountain town (2 wds.) |
| 38% | TESSMONAGHAN | 12 | Reporter-turned-investigator in a series of crime novels by 44-Across (2 wds.) |
| 36% | GLASSHOUSES | 11 | Most recent novel in the mystery series by 40-Across featuring 30-Across (2 wds.) |
| 36% | ONTOUR | 6 | Performing concerts in a series of locations: 2 wds. |
| 36% | JOHNNYBRAVO | 11 | Muscular title character in a 1997-2004 Cartoon Network series: 2 wds. |
| 36% | GOODSHIP | 8 | With 44-Across, boat in a song by 29-Across: 2 wds. |
| 35% | WITCHSSISTER | 12 | First book in a fantasy series about black magic by Phyllis Reynolds Naylor (2 wds.) |
| 34% | POKERFACE | 9 | Natasha Lyonne murder mystery series on Peacock created by 39-Across: 2 wds. |
| 34% | RICHARDCASTLE | 13 | Writer who was the title character in a 2009-2016 crime series: 2 wds. |
| 34% | STEVENUNIVERSE | 14 | Half-human, half-alien title character in a current Cartoon Network series: 2 wds. |
| 34% | DARKOFTHEMOON | 13 | First book in a series of novels by John Sandford featuring 46-Across (4 wds.) |
| 34% | SAMURAIJACK | 11 | Sword-wielding title character in a 2001-2004 and 2017 Cartoon Network series: 2 wds. |
| 34% | CORKOCONNOR | 11 | Former small-town sheriff featured in a series of novels by William Kent Krueger, including "Iron Lake," 18-Across, and 29-Across (2 wds.) |
| 33% | HARPERSISLAND | 13 | American horror mystery series that follows a group who travel for a destination wedding: 2 wds. |
| 33% | RAMONATHEPEST | 13 | One in a series of books by 46-Across about a girl starting kindergarten: 3 wds. |
| 33% | HARDKNOCKLIFE | 13 | Subtitle of the second album in a three-part semiautobiographical series by 39-Across (3 wds.) |
| 33% | JOHNNYENGLISH | 13 | Fictional spy portrayed by Rowan Atkinson in a series of parody films: 2 wds. |
| 33% | HENRYANDRIBSY | 13 | One in a series of books by 46-Across about a boy and his dog: 3 wds. |
| 32% | PADDINGTONBEAR | 14 | Animal voiced by Ben Whishaw in a live-action animated film series (2 wds.) |