| 100% | SONIC | 5 | Video-game character who collects the Chaos Emeralds |
| 54% | MARIO | 5 | Video game character who battles Bowser |
| 54% | MARIO | 5 | Video game character who exclaims "Mamma mia!" |
| 53% | LUIGI | 5 | Plumber character who is Mario's twin brother and sidekick in the video game franchise |
| 53% | DIDDY | 5 | ___ Kong, monkey character who is a sidekick to Donkey Kong in the video game franchise |
| 53% | MARIO | 5 | Video game character who says "It's-a me" |
| 53% | MARIO | 5 | Video game character who grows when he touches mushrooms |
| 52% | SONIC | 5 | Video game character who attacks by rolling into a ball |
| 51% | PACMAN | 6 | Video game character who nibbles up dots in a maze: Hyph. |
| 51% | HEALER | 6 | Video game character type who restores health |
| 50% | NPC | 3 | Video game character controlled by the game |
| 50% | NINTENDO | 8 | Video game company who created the Switch |
| 49% | ORI | 3 | Video game spirit who navigates the Blind Forest |
| 48% | MEGAMAN | 7 | Video game hero who battles the evil Dr. Wily |
| 48% | SIMS | 4 | Video game characters for whom "I'm hungry" is "Oh feebee lay" |
| 48% | RAIDER | 6 | Video game with the character Lara Croft: Tomb __ |
| 48% | MYST | 4 | Video game franchise with the main character Atrus |
| 47% | LARACROFT | 9 | Video game character with the most appearances on magazine covers, per Guinness (1,200+) |
| 46% | PAC | 3 | ___-Man, famous arcade game character who is associated with the color at 42a |
| 45% | MARIO | 5 | First video game character to be honored with a figure in the Hollywood Wax Museum |
| 45% | SONIC | 5 | ___ the Hedgehog, video game character |
| 45% | SONIC | 5 | First video game character to have a balloon in the Macy's Thanksgiving Day Parade |
| 44% | HERLOCK | 7 | ___ Sholmes, character from the video game "Ace Attorney" who was based on Sherlock Holmes |
| 43% | DREAMLAND | 9 | Place where the video game character Kirby lives |
| 43% | DONKEYKONG | 10 | Video game with a gorilla that first featured the main character of 43-Across (2 wds.) |
| 42% | MARIOBROS | 9 | Video game franchise with characters found at the ends of 17-, 20-, 53- and 58-Across |
| 42% | SATOSHITAJIRI | 13 | Japanese video game designer who is the creator of the Pokemon franchise: 2 wds. |
| 42% | LARA | 4 | Video game character Croft |
| 41% | CONTRA | 6 | Run and gun video game published in 1988 by Konami with the characters Bill and Lance |
| 41% | SIMS | 4 | Video-game characters whose "lives" are controlled by the players |