| 100% | NPC | 3 | Video game character controlled by the game |
| 75% | SIMS | 4 | Video-game characters whose "lives" are controlled by the players |
| 63% | ALIEN | 5 | Many a character in the "Star Control" video game series |
| 61% | ZELDA | 5 | Video game character rescued by Link |
| 59% | CONTRA | 6 | Run and gun video game published in 1988 by Konami with the characters Bill and Lance |
| 58% | SONIC | 5 | ___ the Hedgehog, video game character |
| 57% | LUIGI | 5 | Classic video game character portrayed by John Leguizamo (1993) |
| 56% | BALATRO | 7 | 2024 video game partially inspired by the card game Big Two |
| 55% | SONIC | 5 | Video game character who attacks by rolling into a ball |
| 55% | DREAMLAND | 9 | Place where the video game character Kirby lives |
| 54% | AVATAR | 6 | Character created by players in video games |
| 53% | RAIDER | 6 | Video game with the character Lara Croft: Tomb __ |
| 53% | MYST | 4 | Video game franchise with the main character Atrus |
| 53% | NPC | 3 | Video game figure not controlled by a human: Abbr. |
| 52% | LARACROFT | 9 | Video game character with the most appearances on magazine covers, per Guinness (1,200+) |
| 52% | MMO | 3 | Video game played by many people at the same time |
| 52% | FLOSS | 5 | Celebratory move popularized by the video game "Fortnite" |
| 51% | SIMS | 4 | Characters in the video game designer Will Wright's "virtual dollhouse" |
| 51% | ATARI | 5 | Company hurt by the video game crash of 1983 |
| 50% | ELDENRING | 9 | 2022 video game by the developers of the Souls series |
| 50% | SONIC | 5 | Video-game character who collects the Chaos Emeralds |
| 50% | MARIO | 5 | First video game character to be honored with a figure in the Hollywood Wax Museum |
| 50% | SONIC | 5 | First video game character to have a balloon in the Macy's Thanksgiving Day Parade |
| 49% | MARIO | 5 | Main character in the best-selling video game franchise of all time |
| 48% | DONKEYKONG | 10 | Video game with a gorilla that first featured the main character of 43-Across (2 wds.) |
| 48% | MARIOBROS | 9 | Video game franchise with characters found at the ends of 17-, 20-, 53- and 58-Across |
| 48% | TRAIL | 5 | "The Oregon ___," the longest-running video game franchise that was co-created by Don Rawitsch |
| 47% | HERLOCK | 7 | ___ Sholmes, character from the video game "Ace Attorney" who was based on Sherlock Holmes |
| 47% | METRO | 5 | "___ 2033," video game that was inspired by Dmitry Glukhovsky novel of the same title |
| 47% | DUST | 4 | "___: A Tale of the Wired West," single-player video game published by GTE Entertainment |