| 100% | SUPERMARIO | 10 | Video game franchise set in the Mushroom Kingdom (2 wds.) |
| 62% | HALO | 4 | Video game franchise set in the 26th century |
| 58% | SILENTHILL | 10 | Sean Bean/Laurie Holden horror film based on a video game franchise set in a monster-filled town (2 wds.) |
| 52% | MADDENNFL | 9 | Video game franchise that featured 15-Across on the cover of the 2011 version: 2 wds. |
| 52% | SPLINTERCELL | 12 | Tom Clancy video game franchise about a black-ops subdivision within the NSA: 2 wds. |
| 49% | MIKETYSON | 9 | Heavyweight champ who's been featured in the "Punch-Out!!" boxing video game: 2 wds. |
| 49% | GARYCOLEMAN | 11 | "Diff'rent Strokes" star who appears as himself in the 2003 video game "Postal 2": wds. |
| 48% | IDINAMENZEL | 11 | "Wicked" Tony winner who voices characters in the video games "Kingdom Hearts III" and "Disney Infinity" (2 wds.) |
| 48% | AMONGUS | 7 | Video game set in space that went viral in 2020 (2 wds.) |
| 47% | LARRYBIRD | 9 | Celtics great who faced Dr. J and Michael Jordan in the "One-on-One" video game series: 2 wds. |
| 47% | SNOOPDOGG | 9 | "Gin and Juice" rapper who appears as himself in the 2003 video game "True Crime: Streets of LA": 2 wds. |
| 47% | ANGRYBIRDS | 10 | Video game franchise in which the enemies are pigs |
| 47% | MARIOKART | 9 | Nintendo racing video game franchise: 2 wds. |
| 47% | SATOSHITAJIRI | 13 | Japanese video game designer who is the creator of the Pokemon franchise: 2 wds. |
| 46% | MORTALKOMBAT | 12 | Lewis Tan/Jessica McNamee martial arts film based on a video game franchise set at an ultimate fighting tournament (2 wds) |
| 46% | DIEHARD | 7 | Action film set in the fictional Nakatomi Plaza: 2 wds. |
| 46% | BOTTLECAPS | 10 | Twist-off tops used as currency in the video game "Fallout" (2 wds.) |
| 46% | TOAD | 4 | Protector of the Mushroom Kingdom in Super Mario games |
| 45% | AMERICANHUSTLE | 14 | 2013 Christian Bale film set in the 1970s: 2 wds. |
| 45% | THEGOLDBERGS | 12 | ABC comedy series set in the 1980s: 2 wds. |
| 45% | STRANGERTHINGS | 14 | Netflix horror series set in the 1980s: 2 wds. |
| 45% | THEAMERICANS | 12 | FX spy series set in the 1980s: 2 wds. |
| 44% | ADVENTURETIME | 13 | Animated Cartoon Network series set in the Land of Ooo: 2 wds. |
| 44% | HEROSDUTY | 9 | First-person shooter video game in 20-Across: 2 wds. |
| 44% | SOUTHPARK | 9 | Long-running animated series set in the Rockies: 2 wds. |
| 44% | SUGARRUSH | 9 | Kart-racing video game in 20-Across: 2 wds. |
| 44% | DRNO | 4 | First movie in the James Bond franchise: 2 wds. |
| 43% | GHOSTRECON | 10 | Tom Clancy video game franchise about an intelligence-gathering special-ops squad: 2 wds. |
| 43% | RAINBOWSIX | 10 | Tom Clancy video game franchise about a counterterrorist unit with a colorful title: 2 wds. |
| 43% | KEANUREEVES | 11 | Canadian actor who starred in the "Matrix" movie franchise: 2 wds. |