| 100% | MYST | 4 | Video game franchise with the main character Atrus |
| 62% | MARIOBROS | 9 | Video game franchise with characters found at the ends of 17-, 20-, 53- and 58-Across |
| 59% | THESIMS | 7 | Video game franchise with the cheat code "rosebud" |
| 54% | SEGA | 4 | Video game company with the Super Monkey Ball franchise |
| 53% | SEGA | 4 | Video game company with the "Virtua Fighter" franchise since 1993 |
| 52% | SEGA | 4 | Video game company with the After Burner and Virtua Fighter franchises |
| 52% | MARIO | 5 | Main character in the best-selling video game franchise of all time |
| 52% | RAIDER | 6 | Video game with the character Lara Croft: Tomb __ |
| 48% | DONKEYKONG | 10 | Video game with a gorilla that first featured the main character of 43-Across (2 wds.) |
| 48% | LARACROFT | 9 | Video game character with the most appearances on magazine covers, per Guinness (1,200+) |
| 47% | TEMPLERUN | 9 | Video game franchise with evil chaser monkeys |
| 47% | DRAGONQUEST | 11 | Video game franchise with fire-breathing creatures |
| 46% | MARIO | 5 | First video game character to be honored with a figure in the Hollywood Wax Museum |
| 46% | CONTRA | 6 | Run and gun video game published in 1988 by Konami with the characters Bill and Lance |
| 45% | HALO | 4 | Sci-fi video game franchise with militaristic aliens |
| 45% | SIMS | 4 | With “The,” video-game franchise that uses a diamond-shaped “plumbob” to mark a selected character |
| 44% | HALO | 4 | Video game franchise set in the 26th century |
| 44% | LARACROFT | 9 | The main character of the Tomb Raider games |
| 44% | HALO | 4 | Video game series with the protagonist Master Chief |
| 44% | SEGA | 4 | Company with the Streets of Rage video game franchise |
| 44% | ANGRYBIRDS | 10 | Video game franchise in which the enemies are pigs |
| 43% | SUPERMARIO | 10 | Video game franchise set in the Mushroom Kingdom (2 wds.) |
| 43% | SEGA | 4 | Gaming company with the Yakuza franchise |
| 42% | OHARA | 5 | Scarlett ___, the main character in "Gone with the Wind" |
| 42% | NPC | 3 | Video game character controlled by the game |
| 42% | CSI | 3 | Franchise with a ''Hard Evidence'' video game |
| 42% | QBERT | 5 | Video game with a cube-hopping character |
| 42% | MARIO | 5 | Video game character with a large mustache |
| 42% | AAA | 3 | Video game with the highest development budget |
| 42% | SAMUSARAN | 9 | Metroid video game main character |