| 100% | NURSERATCHED | 12 | Villain created by Ken Kesey played by 19-Across and 34-Across (2 wds.) |
| 49% | EMMAWOODHOUSE | 13 | "Handsome, clever, and rich" Jane Austen heroine played by 19-Across and 32-Across (2 wds.) |
| 47% | DWAYNEPRIDE | 11 | Special agent played by 19-Across: 2 wds. |
| 47% | MIKEHAMMER | 10 | Private investigator created by Mickey Spillane played by 43-Across in the 1980s and 1990s (2 wds.) |
| 46% | JESSESTONE | 10 | Fictional detective created by novelist 33-Across and played by actor 43-Across (2 wds.) |
| 43% | PULITZERPRIZE | 13 | Award won by 15-, 19-, 43-, and 52-Across: 2 wds. |
| 42% | CIAAGENT | 8 | Job held by the four characters from 15-, 19-, 31-, and 40-Across: 2 wds. |
| 42% | HELLSKITCHEN | 12 | Cooking competition show created and hosted by 18-Across: 2 wds. |
| 41% | RICHARDKIMBLE | 13 | Role played by 18- and 44-Across: 2 wds. |
| 41% | JETHROGIBBS | 11 | Special agent and former Marine played by Mark Harmon and 30-Across (2 wds.) |
| 41% | CAROLDANVERS | 12 | Alter ego of Captain Marvel played by 13-Across and 27-Across (2 wds.) |
| 41% | JOANWATSON | 10 | Doctor companion to 34-Across, played by Lucy Liu: 2 wds. |
| 41% | LEXLUTHOR | 9 | Superman nemesis played by Gene Hackman and Jesse Eisenberg: 2 wds. |
| 40% | IRONMAN | 7 | Superhero co-created by 41-Across and played by Robert Downey Jr. (2 wds.) |
| 40% | OCTOPUSSGARDEN | 14 | 1969 song recorded by 19-Across, and title of 41-Across's 2014 picture book: 2 wds. |
| 40% | NEWTSCAMANDER | 13 | Character played by 15-Across in "Fantastic Beasts and Where to Find Them": 2 wds. |
| 40% | VANGOGH | 7 | Dutch artist portrayed by 15-Across, 20-Across, and 34-Across: 2 wds. |
| 40% | DOCTORSTRANGE | 13 | Superhero co-created by 41-Across and played by Benedict Cumberbatch (2 wds.) |
| 40% | WEVEGOT | 7 | With 34-Across, 1983 duet by Kenny Rogers and Sheena Easton: 2 wds. |
| 39% | SILENTSPRING | 12 | Book by 19-Across that challenged the use of chemical pesticides and sparked environmentalism: 2 wds. |
| 39% | GORDONMALLOY | 12 | Helmsman and lieutenant played by Scott Grimes on 49-Across (2 wds.) |
| 39% | KELLYGRAYSON | 12 | Commander and first officer played by Adrianne Palicki on 49-Across (2 wds.) |
| 39% | CAPTAINCOLD | 11 | Chilly villain played by Wentworth Miller on "The Flash": 2 wds. |
| 39% | KILLERFROST | 11 | Icy villain played by Danielle Panabaker on "The Flash": 2 wds. |
| 39% | LORDVOLDEMORT | 13 | "Harry Potter" villain played by 49-Across (2 wds.) |
| 39% | BOOKOF | 6 | "The ___" (with 35-Across, satirical Broadway musical created by Trey Parker, Robert Lopez, and Matt Stone: 2 wds. |
| 39% | VITOCORLEONE | 12 | Mafia don played by both 14-Across and 28-Across in the "Godfather" franchise: 2 wds. |
| 39% | CHRISSYSNOW | 11 | Roommate of Janet Wood and Jack Tripper played by 44-Across on 15-Across (2 wds.) |
| 38% | WEATHERWIZARD | 13 | Climate-controlling villain played by Liam McIntyre on "The Flash": 2 wds. |
| 38% | JODIPICOULT | 11 | Bestselling author of more than 30 books, including "My Sister's Keeper," 19-Across, and 34-Across (2 wds.) |