| 100% | DRNO | 4 | Villain with the title role in a 1962 movie that introduced 007: 2 wds. |
| 45% | MICHAELKEATON | 13 | Actor with the title role in 1988's "Beetlejuice": 2 wds. |
| 42% | MIKEMYERS | 9 | "SNL" alum who played the title roles in the "Austin Powers" and "Shrek" movies: 2 wds. |
| 41% | FORRESTGUMP | 11 | Title role played by Tom Hanks in a 1994 Oscar-winning movie: 2 wds. |
| 41% | THEBLACKPANTHER | 15 | Comic book character with the title role in a blockbuster 2018 film |
| 40% | BENPLATT | 8 | "The Politician" star who plays the title role in the movie adaptation of "Dear Evan Hansen": 2 wds. |
| 39% | ARIANAGRANDE | 12 | "7 Rings" singer who reimagined 18-Across in a 2024 hit with the same title: 2 wds. |
| 39% | CAMILACABELLO | 13 | "Trolls Band Together" voice actress who played the title role in the 2021 movie musical "Cinderella" (2 wds.) |
| 38% | IRENEBEDARD | 11 | Actress who voiced the title role in "Pocahontas": 2 wds. |
| 38% | LEADS | 5 | Performers with the biggest roles in a movie |
| 38% | VITOCORLEONE | 12 | Character who has the title role in 15-Across: 2 wds. |
| 38% | HENRYFONDA | 10 | "On Golden Pond" actor who played the title role in 32-Across: 2 wds. |
| 37% | TONYTODD | 8 | "Final Destination" actor who plays the title role in 16-Across: 2 wds. |
| 37% | EPISODEI | 8 | Words before "The Phantom Menace" in a movie title: 2 wds. |
| 37% | JULIEANDREWS | 12 | Actress who won an Oscar for playing the title role in 39-Across: 2 wds. |
| 36% | JULIEANDREWS | 12 | "The Princess Diaries" actress who played the title role in the 1957 TV movie musical "Cinderella" (2 wds.) |
| 36% | EDDIEMURPHY | 11 | "Coming to America" actor who played the title role in 1998's "Dr. Dolittle": 2 wds. |
| 36% | DOCTORSTRANGE | 13 | Marvel superhero movie starring Benedict Cumberbatch in the title role: 2 wds. |
| 36% | OLIVIAMUNN | 10 | "The Predator" actress who plays the title role in "Violet": 2 wds. |
| 36% | RUSSELLCROWE | 12 | He played the title role in 2010's "Robin Hood": 2 wds. |
| 35% | EWANMCGREGOR | 12 | "Beauty and the Beast" actor who plays the title role in the new movie "Christopher Robin": 2 wds. |
| 35% | THEGRINCH | 9 | Title villain played by Jim Carrey in a 2000 Christmas movie (2 wds.) |
| 35% | CHARLIEWILSON | 13 | Title role played by Tom Hanks in a 2007 comedy-drama: 2 wds. |
| 35% | LARRYCROWNE | 11 | Title role played by Tom Hanks in a 2011 romantic comedy: 2 wds. |
| 35% | SCARLETTOHARA | 13 | Vivien Leigh's role in "Gone With the Wind": 2 wds. |
| 35% | RHETTBUTLER | 11 | Clark Gable's role in "Gone With the Wind": 2 wds. |
| 35% | IRONMAN | 7 | 2008 Marvel movie starring Robert Downey Jr. in the title role: 2 wds. |
| 35% | MELANIEWILKES | 13 | Olivia de Havilland's role in "Gone With the Wind": 2 wds. |
| 34% | SHERLOCKHOLMES | 14 | 2009 period mystery movie starring Robert Downey Jr. in the title role: 2 wds. |
| 34% | JAREDLETO | 9 | "Blade Runner 2049" actor who plays the title role in "Morbius" (2 wds.) |