| 100% | UPWORTHY | 8 | Viral-content site that popularized the two-clause headline |
| 43% | MEME | 4 | Content that goes viral on the internet |
| 39% | THEOC | 5 | Two-thousands teen drama that popularized the portmanteau “Chrismukkah” |
| 36% | ALS | 3 | Disease that popularized the Ice Bucket Challenge |
| 36% | CONEHEADS | 9 | TV family that popularized the term "parental unit" |
| 36% | DREDAY | 6 | 1992 rap song that popularized the term "bootylicious" |
| 36% | THEOC | 5 | 2000s teen drama that popularized the term Chrismukkah |
| 36% | MAD | 3 | Magazine that popularized the phrase "What, me worry?" |
| 35% | IROBOT | 6 | Classic work of fiction that popularized the Three Laws |
| 35% | THEARTOFTHEDEAL | 15 | Book that popularized the phrase “truthful hyperbole,” in 1987 |
| 35% | CLUELESS | 8 | 1995 teen comedy that popularized the phrase "As if!" |
| 35% | KIDNEYS | 7 | The two matching organs that filter blood |
| 35% | DANCEPARTNERS | 13 | The two that it takes to tango |
| 35% | PENNY | 5 | "A ___ saved is worth two in the bush," example of 50a that encourages being content with what you have |
| 34% | WEEKEND | 7 | The two days that everyone looks forward to |
| 34% | REDDIT | 6 | Site that's "the front page of the Internet" |
| 33% | IBM | 3 | ___ 5150, computer model released in 1981 that popularized the "personal computer" concept |
| 33% | WHATSMYLINE | 11 | TV show that popularized the phrase "Is it bigger than a breadbox?" |
| 33% | ETSY | 4 | Site that acquired the music-gear marketplace Reverb in 2019 |
| 33% | AOL | 3 | Company that popularized instant messaging in the 1990s |
| 33% | JAW | 3 | One of the two that helps you chew |
| 33% | PERU | 4 | One of the two countries that border Ecuador |
| 33% | ALABAMAJUBILEE | 14 | 1915 song that popularized the phrase "Hail! Hail! The gang's all here" |
| 33% | MTV | 3 | Music channel launched in 1981 that popularized the concept of "video jockey": Abbr. |
| 32% | VIRAL | 5 | Content that rapidly spreads over the internet |
| 32% | IONIA | 5 | Site of two of the Ancient Wonders |
| 32% | PEPSI | 5 | Brand that introduced the two-liter bottle |
| 32% | ETSY | 4 | Online site that's in the tradition of craft fairs |
| 32% | EBAY | 4 | Web site that includes the heading "Dolls & Bears" |
| 31% | VOX | 3 | News site that hosts the "Future Perfect" reporting project |