| 100% | HORACEANDPETE | 13 | Web series set in a Brooklyn bar that costarred Edie Falco: 3 wds. |
| 40% | AVIEWFROM | 9 | With 23-Down, Arthur Miller play set in a Brooklyn waterfront neighborhood: 3 wds. |
| 38% | THEGOODFIGHT | 12 | CBS All Access series set in the world of a Chicago law firm: 3 wds. |
| 37% | STARTREKPICARD | 14 | CBS All Access series set in the future world of a retired Starfleet admiral: 3 wds. |
| 35% | SOLDIERSOFTHE | 13 | "Captain Power and the ___ Future," 1987 Canadian-American sci-fi series set in the 22nd century following a cybernetic revolt: 3 wds. |
| 35% | SOUTHPARK | 9 | Animated Comedy Central series set in a small town in Colorado: 2 wds. |
| 33% | CHEERS | 6 | NBC sitcom set in a bar that starred Ted Danson |
| 33% | ORANGEIS | 8 | With 33- and 52-Across, television series set in a women's prison: 2 wds. |
| 33% | NURSEJACKIE | 11 | Showtime comedy-drama set in a hospital that ended this summer: 2 wds. |
| 33% | THEBLACKTULIP | 13 | Alexandre Dumas historical novel set in Holland that has a flower in its title (3 wds.) |
| 32% | THECOSBYSHOW | 12 | 1984-1992 NBC sitcom set in Brooklyn: 3 wds. |
| 32% | TELLMEASTORY | 12 | CBS All Access series set in a dark, modern-day world based on classic fairy tales: 4 wds. |
| 31% | JACKTAYLOR | 10 | Mystery drama series set in Ireland starring Iain Glen as a private investigator (2 wds.) |
| 31% | NURSEJACKIE | 11 | Showtime series that starred Edie Falco: 2 wds. |
| 31% | THESOPRANOS | 11 | HBO series that featured Edie Falco: 2 wds. |
| 31% | NURSE | 5 | "___ Jackie," TV series starring Edie Falco that is set in New York City |
| 30% | THEGOODPLACE | 12 | Kristen Bell TV series set in ... heaven? (3 wds.) |
| 30% | THEGILDEDAGE | 12 | HBO series set in 1880s New York City, featuring Christine Baranski as socialite Agnes van Rhijn: 3 wds. |
| 30% | FAMILYMATTERS | 13 | Sitcom set in Chicago that was a spin-off of "Perfect Strangers" (2 wds.) |
| 30% | STRANGERTHINGS | 14 | Netflix series set in the 1980s in which single mom Joyce Byers contends with a supernatural monster: 2 wds. |
| 30% | MICHAELJFOX | 11 | 2000 Emmy winner, Outstanding Lead Actor in a Comedy Series (for "Spin City"): 3 wds. |
| 30% | TVS | 3 | Sets in a bar |
| 30% | THENICKELBOYS | 13 | Colson Whitehead novel set in a Florida reform school (3 wds.) |
| 30% | VIFEETUNDER | 11 | 2000s series set in a funeral home |
| 30% | EMPRESSORCHID | 13 | Anchee Min historical novel set in China that has a flower in its title (2 wds) |
| 30% | RAMONATHEPEST | 13 | One in a series of books by 46-Across about a girl starting kindergarten: 3 wds. |
| 29% | THEFLINTSTONES | 14 | Television series set in Bedrock that debuted in 1960 as the first animated series to run in prime time (2 wds.) |
| 29% | THENICKELBOYS | 13 | 2019 Colson Whitehead novel set in a Florida reform school (3 wds.) |
| 29% | CSI | 3 | CBS series set in a Vegas crime lab |
| 29% | ROOM | 4 | "___ 104" (HBO anthology series set in a motel) |