| 100% | ANTHONYHOPKINS | 14 | Welsh actor who played American president Richard Nixon in "Nixon": 2 wds. |
| 68% | DANIELDAYLEWIS | 14 | British-Irish actor who played American president Abraham Lincoln in "Lincoln": 2 wds. |
| 57% | DUSTINHOFFMAN | 13 | American actor who played Dorothy Michaels in "Tootsie": 2 wds. |
| 57% | CHRISTIANBALE | 13 | Welsh-born actor who played Dick Cheney in "Vice": 2 wds. |
| 57% | RICHARDBURTON | 13 | Welsh-born actor who played Marc Antony in "Cleopatra": 2 wds. |
| 55% | JAMESCAAN | 9 | Jewish actor who played Italian American Sonny Corleone in "The Godfather": 2 wds. |
| 55% | JOHNKRASINSKI | 13 | American actor who plays Jim Halpert in "The Office": 2 wds. |
| 54% | NICKOFFERMAN | 12 | "Parks and Recreation" actor who plays the US president in "Civil War": 2 wds. |
| 54% | DUSTINHOFFMAN | 13 | Actor who played 43-Across in the movie "All the President's Men": 2 wds. |
| 53% | DAVIDOYELOWO | 12 | British-Nigerian actor who played American civil rights leader Martin Luther King, Jr., in "Selma": 2 wds. |
| 53% | JONAHHILL | 9 | American actor who plays Lewis in the American comedy film "The Beach Bum": 2 wds. |
| 53% | ANTHONYHOPKINS | 14 | Welsh-born actor who played Hannibal Lecter in "The Silence of the Lambs": 2 wds. |
| 53% | HARRISONFORD | 12 | "Blade Runner" actor who played President James Marshall in "Air Force One": 2 wds. |
| 52% | CLIFFROBERTSON | 14 | "Charly" actor who played president-to-be John Kennedy in "PT 109" (1963): 2 wds. |
| 52% | MATTHEWRHYS | 11 | "The Americans" actor who plays the title role in HBO's "Perry Mason": 2 wds. |
| 52% | MCCONAUGHEY | 11 | Matthew ___, American actor who plays Moondog in the American comedy film "The Beach Bum": 2 wds. |
| 52% | WILLIAMDANIELS | 14 | "Boy Meets World" actor who played president-to-be John Adams in "1776" (1972): 2 wds. |
| 51% | BRYANCRANSTON | 13 | American actor who played the lead in "Breaking Bad" and also starred in "Malcolm in the Middle": 2 wds. |
| 51% | ALANRICKMAN | 11 | "Harry Potter" actor who plays President Ronald Reagan in "The Butler" (2 wds.) |
| 51% | BRADLEYCOOPER | 13 | "The Hangover" actor who plays soldier Chris Kyle in "American Sniper": 2 wds. |
| 51% | JASONBIGGS | 10 | "American Pie" actor who plays the father in 18-Across: 2 wds. |
| 51% | MAHERSHALAALI | 13 | Actor who played Chiron's mentor Juan in "Moonlight": 2 wds. |
| 51% | WILLFORTE | 9 | Actor who plays Woody's son David in "Nebraska": 2 wds. |
| 50% | BURTLANCASTER | 13 | Actor who played baseball's Jim Thorpe in the 1951 biopic "Jim Thorpe — All-American": 2 wds. |
| 50% | JEFFREYWRIGHT | 13 | "American Fiction" actor who plays American artist Jean-Michel Basquiat in the film "Basquiat" (2 wds.) |
| 50% | EUGENELEVY | 10 | "Schitt's Creek" actor who played Jim's dad Noah in "American Pie": 2 wds. |
| 50% | LIEVSCHREIBER | 13 | "Spotlight" actor who plays President Lyndon B. Johnson in "The Butler" (2 wds.) |
| 50% | ERICBANA | 8 | Actor who played 32-Across in a 2003 film: 2 wds. |
| 50% | EDWARDNORTON | 12 | Actor who played 32-Across in a 2008 film: 2 wds. |
| 50% | MICHAELKEATON | 13 | Actor who plays Vulture, the villain in 16-Across: 2 wds. |