| 100% | ULNA | 4 | What's got the upper hand? |
| 68% | ARMWRESTLE | 10 | Try to get the upper hand in competition? |
| 58% | POT | 3 | What the best hand may get you |
| 57% | ASCENT | 6 | What's on the up and up? |
| 56% | INHIS | 5 | "He's Got the Whole World ___ Hands" |
| 55% | TIME | 4 | What's up at the deadline? |
| 53% | BETTEROFF | 9 | Having the upper hand |
| 53% | LED | 3 | Had the upper hand |
| 52% | FATJOE | 6 | What's Luv and All the Way Up rapper |
| 52% | TIME | 4 | What's up at the end of an exam? |
| 52% | USE | 3 | "Oh, what's the ___?" ("I give up") |
| 52% | QUEPASA | 7 | What’s up in the Sierra Madre? |
| 52% | NOREST | 6 | What the weary get, it's said |
| 51% | EDAM | 4 | What's wrapped up in the whole ball of wax? |
| 51% | IGIVE | 5 | "___ up, what's the answer?": 2 wds. |
| 50% | ASH | 3 | What got on Santa's clothes, per the poem |
| 50% | ANTE | 4 | Up the ___ (increase what's at stake) |
| 50% | OPENS | 5 | Gets the crowd warmed up |
| 49% | HITCHINGARIDE | 13 | Getting picked up by the side of the road ... or what 20-, 30- and 39-Across are literally doing? |
| 49% | CONTENTS | 8 | Page that lists what's coming up in the book |
| 49% | UPPER | 5 | Get the ___ hand (gain an advantage) |
| 49% | PUTT | 4 | What might get the ball rolling |
| 49% | INCLINE | 7 | What might get the ball rolling |
| 48% | ATSIX | 5 | When one hand's up and the other's down |
| 48% | ATSIX | 5 | When a hand's up and the other's down |
| 47% | HIS | 3 | "He's got the whole world in __ handsÉ" |
| 47% | HES | 3 | "___ Got the Whole World in His Hands" |
| 47% | HES | 3 | "___ got the whole world in his hands..." |
| 47% | HES | 3 | "___ got the whole world in his hands ..." |
| 47% | ENTER | 5 | What's the key to getting from the end of a line to the start? |