| 100% | SLEEPERAGENTS | 13 | What the lead characters in "The Americans" actually are: 2 wds. |
| 60% | ANTHONYRAMOS | 12 | "A Star Is Born" actor who plays Usnavi, the lead character in 18-Across: 2 wds. |
| 57% | SIXWEEKS | 8 | With 33-Across, what is forecast if the title character in 14-Across sees his shadow: 2 wds. |
| 57% | JOEFRAZIER | 10 | American professional boxer who defeated Muhammad Ali in what is famously called the "Fight of the Century": 2 wds. |
| 55% | CHANNINGTATUM | 13 | "The Vow'' actor who voices one of the lead characters in "Smallfoot'': 2 wds. |
| 53% | CLARKKENT | 9 | The lead character in "Smallville" who eventually becomes Superman, played by Tom Welling: 2 wds. |
| 52% | RICKSANCHEZ | 11 | Genius but cynical scientist, one of the lead characters in "Rick and Morty" : 2 wds. |
| 52% | ROTTENEGG | 9 | What the "last one in" is, when running to the pool: 2 wds. |
| 51% | NATALIEDORMER | 13 | The actress from the show "Game of Thrones" who was the lead actress in the movie "In Darkness": 2 wds. |
| 51% | RICHARDCASTLE | 13 | Writer who was the title character in a 2009-2016 crime series: 2 wds. |
| 50% | HUMANCLONES | 11 | What all of the identical characters on 18-Across are: 2 wds. |
| 50% | MICKJAGGER | 10 | Lead singer of the Rolling Stones who was knighted in 2003: 2 wds. |
| 50% | LINUSPAULING | 12 | American chemist who was awarded the Nobel Peace Prize in 1962: 2 wds. |
| 50% | BRUCEWILLIS | 11 | American actor who was in the music video of Gorillaz "Stylo": 2 wds. |
| 50% | KERIRUSSELL | 11 | "The Americans" star who was nominated for the 2017 Emmy Award for Outstanding Lead Actress in a Drama Series (2 wds.) |
| 50% | PIPERCHAPMAN | 12 | Lead character played by Taylor Schilling on "Orange Is the New Black": 2 wds. |
| 49% | SOPHIETURNER | 12 | The actress from the show "Game of Thrones" who was the lead actress in the movie "Josie": 2 wds. |
| 49% | ORCA | 4 | What the title character in "Free Willy" was |
| 49% | MELGIBSON | 9 | Actor who played the lead character, "Mad" Max Rockatansky in the 1979 film "Mad Max": 2 wds. |
| 49% | INDIANAJONES | 12 | From executive producer Steven Spielberg, lead character in 1981 movie "Raiders of the Lost Ark" : 2 wds. |
| 49% | CRISTIEKERR | 11 | American golfer who was #1 in the LPGA for five weeks in 2010: 2 wds. |
| 49% | APE | 3 | What the main character in "Mighty Joe Young" was |
| 49% | ELISABETHMOSS | 13 | American actress who plays the lead role of Offred in the series in 18a: 2 wds. |
| 49% | PETERGRIFFIN | 12 | The main character and father of the family in the American sitcom, "Family Guy": 2 wds. |
| 49% | DAVEGROHL | 9 | American musician who was the drummer for Nirvana and lead vocalist of Foo Fighters: 2 wds. |
| 49% | PYGMYSHREW | 10 | The American ___, a creature believed to be the second smallest mammal in the world: 2 wds. |
| 49% | ISLANUBLAR | 10 | The fictional Central American island in Costa Rica which is the setting for 26a: 2 wds. |
| 49% | JAMESCORDEN | 11 | "The Late Late Show with ___" host who voices another lead character in "Smallfoot'': 2 wds. |
| 48% | JANEADDAMS | 10 | First American woman to be awarded the Nobel Peace Prize, in 1931: 2 wds. |
| 48% | FINALFRONTIER | 13 | With "The," what "space" is, in the intro to 5-/58-Across: 2 wds. |