| 100% | LEMONS | 6 | When life gives you these, stay optimistic! |
| 57% | LEMONADE | 8 | When life gives you lemons, make __ |
| 56% | LEMONADE | 8 | When life gives you lemons, make it |
| 53% | LEMONADES | 9 | Make them when life gives you yellow citrus fruits |
| 52% | LEMONS | 6 | If life gives you these, make a cool, sweet drink |
| 50% | LEMONS | 6 | "When life gives you ___ . . ." |
| 48% | MAKELEMONADE | 12 | What to do when life gives you the proverbial items hidden in 17-, 27- and 48-Across |
| 47% | OPTIMISM | 8 | "When life gives you lemons, make lemonade" outlook |
| 47% | ANSWERS | 7 | You are given these when you ask questions |
| 43% | UNDIVIDEDATTENTION | 18 | What you are giving when you contemplate this puzzle’s theme? |
| 42% | WHEN | 4 | "___ life gives you lemons..." |
| 42% | CAPSLOCK | 8 | IT GIVES YOU THIS |
| 42% | SHIFTKEY | 8 | IT GIVES YOU THIS |
| 41% | LIP | 3 | When being sassy, you're giving someone this |
| 41% | WHEN | 4 | "___ Life Gives You Tangerines" (Netflix series) |
| 39% | TWELVE | 6 | *17a times 40a will give you this answer |
| 39% | TEN | 3 | *27a times five will give you this answer |
| 38% | AREA | 4 | A function's definite integral will give you this |
| 38% | WHAT | 4 | "When life gives you lemonade, make lemons. Life will be all like, '___?!'" quote by Phil Dunphy on the TV series "Modern Family" |
| 37% | ANKH | 4 | When you look around, you may see this ancient Egyptian symbol shaped like a "T" with a loop that represents life (4/5) |
| 37% | NOW | 3 | When you're reading this |
| 37% | EYELID | 6 | This moves when you wink |
| 37% | TODAY | 5 | When you're reading this |
| 37% | LEMON | 5 | Life may give this fruit |
| 36% | DOB | 3 | When you entered this world: Abbr. |
| 36% | NOW | 3 | When you're reading this clue |
| 36% | EVENTRALEE | 10 | When you'll solve this puzzle? |
| 36% | TODAY | 5 | When you're doing this puzzle |
| 36% | TODAY | 5 | When you're solving this puzzle |
| 36% | ENGINE | 6 | You might give this a gun |