| 100% | KATEMIDDLETON | 13 | Wife of 47-Across since April 2011: 2 wds. |
| 45% | JUNECARTER | 10 | Wife of 17-Across, part of a famous family of singers: 2 wds. |
| 44% | CHRISSYTEIGEN | 13 | Model/actress (and wife of John Legend) who cohosts 15-Across: 2 wds. |
| 42% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 41% | XANDERHARRIS | 12 | Geeky friend of 47-Across played by Nicholas Brendon (2 wds.) |
| 41% | ANNETTEBENING | 13 | Actress and wife of 18-Across, who also appears in "Rules Don't Apply": 2 wds. |
| 40% | TREVORNOAH | 10 | Host of 27-Across since 2015 (2 wds.) |
| 39% | ROBINWRIGHT | 11 | Actor from "Forrest Gump", who plays the wife of the character played by 18-Across in "House of Cards": 2 wds. |
| 39% | JOEMANTEGNA | 11 | Actor who has played David Rossi on 47-Across since 2007 (2 wds.) |
| 39% | PAGETBREWSTER | 13 | Actress who has played Emily Prentiss on 47-Across since 2006 (2 wds.) |
| 37% | MARGARETBUNDY | 13 | The wife of Al Bundy on "Married... with Children," portrayed by Katey Sagal: 2 wds. |
| 37% | MARISCRANE | 10 | Unseen wife of Frasier's brother Niles on the 1993-2004 sitcom "Frasier": 2 wds. |
| 37% | MRSCOLUMBO | 10 | Unseen wife of Peter Falk's character on a 1971-1978 detective show: 2 wds. |
| 37% | HOPEDAVIS | 9 | "Wayward Pines" actress who plays the wife of a mob boss on 54-Across (2 wds.) |
| 36% | GLEN | 4 | Relative of 47 Across |
| 36% | ARTS | 4 | Part of 47 Across |
| 36% | OIL | 3 | Part of 47 Across |
| 35% | LADY | 4 | Wife of 57 Across |
| 35% | BRETTSOMERS | 11 | Saucy-tongued wife of Jack Klugman who was a regular panelist on the 1970s version of "Match Game": 2 wds. |
| 35% | SUSIEESSMAN | 11 | Actress who plays the foul-mouthed wife of the main character's manager Jeff on "Curb Your Enthusiasm": 2 wds. |
| 35% | CINDERELLAMAN | 13 | 2005 film in which Renée Zellweger plays the wife of an injured boxer trying to revive his career: 2 wds. |
| 34% | AUNT | 4 | Wife of a 2-Down |
| 34% | LADYBIRD | 8 | Nickname of LBJ's wife: 2 wds. |
| 33% | JURASSICWORLD | 13 | With 47-Across, 2018 sci-fi thriller starring 28-Across/30-Across and a lot of CGI dinosaurs (2 wds.) |
| 33% | ISEE | 4 | 2 wds to show understanding of something |
| 33% | ANDYREID | 8 | Head coach of the 21-Across/36-Across since 2013 (2 wds.) |
| 33% | MARYJANE | 8 | Wife of Peter Parker voiced by Zoë Kravitz in "Spider-Man: Into the Spider-Verse" (2 wds.) |
| 32% | LARRYMCMURTRY | 13 | Author of 14-Across: 2 wds. |
| 32% | BRYANCRANSTON | 13 | Star of 17-Across: 2 wds. |
| 32% | MARTINSHEEN | 11 | Portrayer of 29-Across: 2 wds. |