| 100% | MIB | 3 | Will Smith sci-fi series, briefly |
| 81% | MIB | 3 | Will Smith sci-fi series |
| 64% | IROBOT | 6 | Will Smith sci-fi movie |
| 62% | IROBOT | 6 | Will Smith sci-fi film set in 2035 |
| 61% | IAMLEGEND | 9 | 2007 Will Smith sci-fi flick |
| 61% | IROBOT | 6 | 2004 Will Smith sci-fi film |
| 59% | IAM | 3 | "___ Legend" (2007 Will Smith sci-fi movie): 2 wds. |
| 58% | AFTEREARTH | 10 | "Elemental" 2013 Will Smith sci-fi action film: 2 wds. |
| 54% | MIB | 3 | Will Smith/Tommy Lee Jones sci-fi hit, for short |
| 52% | STARTREK | 8 | Sci fi series with Captains Kirk, Picard, Janeway |
| 51% | MIB | 3 | Sci-fi film series whose 2019 installment is subtitled "International," familiarly |
| 51% | MIB | 3 | Will Smith series, for short |
| 50% | MIB | 3 | 1997 Smith/Jones sci-fi comedy, briefly |
| 49% | ARTOO | 5 | Iconic sci-fi character whose sounds were designed by Ben Burtt, briefly |
| 48% | DANIELX | 7 | Sci-fi series, cowritten by 16-Across, whose title hero is an alien teenage boy: 2 wds. |
| 48% | BRAVENEWWORLD | 13 | 2020 Peacock sci-fi series that was based on an Aldous Huxley novel: 3 wds. |
| 48% | MIB | 3 | Will Smith/Tommy Lee Jones film series, for short |
| 48% | MIB | 3 | Will Smith/Tommy Lee Jones movie series, for short |
| 47% | ATLANTIS | 8 | "Stargate ___," sci-fi TV series that is a spin-off of "Stargate SG-1" |
| 47% | CARBON | 6 | "Altered ___," cyberpunk sci-fi TV series starring Chris Conner that is set in 2384 |
| 47% | BEL | 3 | "The Fresh Prince of ___-Air," Will Smith series |
| 46% | BRAVE | 5 | "___ New World," sci-fi TV series that was adapted from Aldous Huxley's banned novel |
| 46% | MEN | 3 | "___ in Black" (sci-fi comedy movie starring Will Smith) |
| 45% | FIREFLY | 7 | Critically acclaimed 2002 sci-fi drama series starring Nathan Fillion that was canceled after 1 season |
| 45% | IAMLEGEND | 9 | 2007 sci-fi film starring Will Smith and Alice Braga |
| 45% | HUMAN | 5 | "Almost ___," critically acclaimed 2013 sci-fi drama series starring Karl Urban that was canceled after one season |
| 44% | TREK | 4 | Sci-fi series "Star ___" |
| 44% | ETS | 3 | Sci-fi series extras |
| 44% | STARTREK | 8 | NBC's sci-fi series which was canceled after three seasons but went on to achieve cult status: 2 wds. |
| 44% | GALACTICA | 9 | Dystopian sci-fi TV series "Battlestar ___" by Glen A. Larson, where humans are forced to abandon their planet |