| 100% | OWEN | 4 | Wilson of "The Life Aquatic With Steve Zissou" |
| 58% | ZISSOU | 6 | "The Life Aquatic With Steve ___" (2004 film) |
| 43% | EDEN | 4 | Garden with the tree of life |
| 43% | ISIS | 4 | Goddess with the gift of life |
| 42% | ANTS | 4 | Life study of the biologist E. O. Wilson |
| 41% | NERDS | 5 | "Triumph of the ___," 1996 documentary featuring interviews with Steve Jobs and other entrepreneurs |
| 41% | EMT | 3 | Pro associated with the Star of Life emblem: abbr. |
| 41% | AUTO | 4 | Prefix with "biography" for the story of one's life |
| 40% | BRIAN | 5 | Wilson of the Beach Boys |
| 40% | OWEN | 4 | Wilson of the Frat Pack |
| 39% | OWEN | 4 | Wilson of the Disney+ series "Loki" |
| 39% | ANN | 3 | ___ Wilson of the band Heart |
| 39% | THEOFFICE | 9 | Comedy series about the everyday lives of employees, starring Steve Carell: 2 wds. |
| 38% | KANYE | 5 | Rapper with the new album "The Life of Pablo" |
| 38% | OWEN | 4 | Wilson of the 2023 movie "Haunted Mansion" |
| 38% | REBEL | 5 | ___ Wilson, "Pitch Perfect" actress with a law degree from the University of New South Wales |
| 38% | DIETZ | 5 | Howard —, US lyricist of Broadway musicals Jennie, Revenge with Music and The Gay Life |
| 38% | RILEY | 5 | The life of ___ |
| 38% | ERICCARTMAN | 11 | One of the central "South Park," figures, the elementary school student who lives with his single mother: 2 wds. |
| 38% | PARANORMAL | 10 | "___ Activity," 2007 found footage film that follows the lives of a couple with a supernatural presence in their home |
| 38% | BOB | 3 | With 66-Across, choreographer whose life is depicted in the starts of 19-, 36- and 50-Across |
| 38% | FRIED | 5 | 1991 film with the tagline "The secret of life? The secret's in the sauce" |
| 38% | OWEN | 4 | Actor Wilson of the "Zoolander" movies |
| 38% | ANN | 3 | Singer Wilson of the band Heart |
| 38% | NANCY | 5 | Singer Wilson of the band Heart |
| 38% | EASE | 4 | Quality of the life of Riley |
| 37% | LAVIE | 5 | The life of Paris? |
| 37% | EASE | 4 | The life of Riley |
| 37% | GOODFELLAS | 10 | Martin Scorsese's crime film based on the life of Henry Hill who was associated with the Lucchese crime family |
| 37% | ANG | 3 | With 16-Down, the director of "Life of Pi" |