| 100% | THEWASP | 7 | Winged title character of a 2018 Marvel movie |
| 48% | PETER | 5 | Title character of a Prokofiev favorite |
| 48% | BORAT | 5 | Title character of a 2006 mockumentary |
| 48% | EXORCIST | 8 | Title character of a Blatty novel |
| 48% | AIDA | 4 | Title character of a Verdi opera |
| 47% | JAMESMCAVOY | 11 | "X-Men: Apocalypse" star who played the title character of 28-Across in a 2015 movie: 2 wds. |
| 47% | LILO | 4 | Title character of a 2002 Disney film |
| 47% | DIEGO | 5 | Title character of a "Dora the Explorer" spinoff |
| 47% | DARKO | 5 | Title character of a Jake Gyllenhaal cult classic |
| 47% | APU | 3 | Title character of a Satyajit Ray film trilogy |
| 47% | LOLITA | 6 | Title character of a controversial book by Nabokov |
| 46% | ZOOLANDER | 9 | Dimwitted title character of a 2001 comedy |
| 46% | SARA | 4 | Sister ___, title character of a 1970 film |
| 45% | ANANG | 5 | Title character of a 1988 They Might Be Giants song |
| 45% | ALF | 3 | Furry alien title character of a 1980s sitcom |
| 45% | ALF | 3 | Furry title character of a 1986-1990 sitcom |
| 45% | LILO | 4 | Hawaiian title character of a 2002 Disney film |
| 45% | BONZO | 5 | Pajama-clad title character of a '51 film |
| 45% | POTTER | 6 | Harry __, title character of a series by JK Rowling |
| 43% | RYAN | 4 | Title character in a Spielberg movie |
| 43% | SONICTHE | 8 | With 42-Across, speedy blue title character of a 2020 film: 2 wds. |
| 43% | GARFIELD | 8 | Fictional lasagna-loving cat who is the title character of a comic strip |
| 43% | TEEN | 4 | Title character of "Ms. Marvel" or "Love, Victor," age-wise |
| 42% | ULEE | 4 | Title character in a 1997 bee movie |
| 42% | GEORGYGIRL | 10 | Title song of a 1966 hit movie |
| 42% | MOANA | 5 | Title heroine of a 2016 animated movie |
| 42% | MARS | 4 | Whence the title character of “Stranger in a Strange Land” |
| 42% | MODELTHOR | 9 | Action figure of a Marvel character? |
| 42% | CINDERELLA | 10 | 2015 movie version of a classic fairy tale, with 15-Across as the title character |
| 41% | GATSBY | 6 | Title character of classic American literature who is obsessed with a green light |