| 100% | AMINO | 5 | With 16-Across, component of most proteins |
| 60% | BORIS | 5 | With 16 Across, political resignee of July 2022 |
| 57% | ONE | 3 | With 16-Down, size of many an amuse-bouche |
| 53% | IRAS | 4 | Components of many a 28-Across, for short |
| 52% | BOOBY | 5 | With 127 Across, one of many devices thwarting the burglars in "Home Alone" |
| 52% | HIDDEN | 6 | With 16-Across, the theme of this puzzle |
| 52% | ELM | 3 | With 16-Across, target of some bark beetles |
| 51% | TERRENCE | 8 | With 16-Across, portrayer of Lucious Lyon on "Empire" |
| 50% | LISA | 4 | With 16-Across, "Lady Tan's Circle of Women" novelist |
| 50% | ART | 3 | With 16-Across, style of L.A.'s Griffith Observatory |
| 50% | TOMATO | 6 | Component of many clubs |
| 50% | WHITENER | 8 | Component of many detergents |
| 50% | IMAGES | 6 | Components of many CAPTCHAs |
| 49% | LOVEAND | 7 | With 16-Across, subtitle of 2022's "Thor" movie: 2 wds. |
| 49% | TENSEST | 7 | Most filled with 16-Across |
| 49% | MELON | 5 | Component of most fruit salads |
| 49% | ROTOR | 5 | Component of many lawn mowers |
| 49% | LAB | 3 | Component of many science courses |
| 49% | PLACEBO | 7 | Component of many a trial |
| 49% | ADS | 3 | Components of many free apps |
| 49% | DICE | 4 | Components of many board games |
| 49% | COMBS | 5 | Components of many barbershop logos |
| 49% | ANIMAL | 6 | With 16-Across, Nintendo game in which players encounter many different species |
| 49% | STEVE | 5 | With 16-Across, championship-winning head coach of the Golden State Warriors |
| 49% | VINCENT | 7 | With 16-Across, Post-Impressionist painter of "Sunflowers" and "The Starry Night" |
| 48% | TOGO | 4 | With 16 Across, drive-thru transaction |
| 48% | LAB | 3 | Component of many college science courses |
| 48% | HISTIDINE | 9 | Constituent of many proteins |
| 47% | FESTIVAL | 8 | With 16 Across, another name for Hanukkah |
| 47% | JULIE | 5 | With 16 Across, Downtown ___ (former MTV personality) |