| 100% | GLENN | 5 | With 27-Across, "Fatal Attraction" actress who plays Dr. Scott in "Swan Song": 2 wds. |
| 54% | GLENNCLOSE | 10 | "Fatal Attraction" actress who played Iris Gaines, Roy Hobbs's girlfriend, in 18-Across: 2 wds. |
| 52% | ANNEARCHER | 10 | Actress who played Beth Gallagher, the wife, in "Fatal Attraction": 2 wds. |
| 52% | GLENNCLOSE | 10 | Actress who played Alex Forrest, the "other woman," in "Fatal Attraction": 2 wds. |
| 51% | KEELEYHAWES | 11 | "The Missing" actress who plays Dr. Kira Manning in the "Echoes" spin-off of 18-Across: 2 wds. |
| 50% | DIANEKRUGER | 11 | Actress who plays Dr. Abigail Chase in the "National Treasure" films: 2 wds. |
| 50% | PIPERLAURIE | 11 | "Carrie" actress who played 27-Across's mother in "Children of a Lesser God": 2 wds. |
| 49% | RACHELMCADAMS | 13 | Actress who plays Dr. Christine Palmer in "Doctor Strange in the Multiverse of Madness": 2 wds. |
| 49% | FELICITYJONES | 13 | "The Theory of Everything" actress who plays Dr. Sienna Brooks in "Inferno": 2 wds. |
| 49% | VICKILAWRENCE | 13 | Actress who played Mama Thelma Harper in "The Family" skits with 38-Across (2 wds.) |
| 49% | EVELYNKEYES | 11 | Actress who played Suellen O'Hara in the film "Gone With the Wind": 2 wds. |
| 49% | LUCYLIU | 7 | "Kill Bill" actress who plays Dr. Watson in CBS's "Elementary": 2 wds. |
| 48% | SANDRABULLOCK | 13 | "Gravity" actress who plays a romance novelist in 27-Across (2 wds.) |
| 48% | MARYMCDONNELL | 13 | "Independence Day" actress who played Stands With a Fist in "Dances With Wolves": 2 wds. |
| 47% | LEAMICHELE | 10 | Actress who plays 17-Across' girlfriend and was 29-Across' girlfriend in real life: 2 wds. |
| 47% | CHLOESEVIGNY | 12 | "Russian Doll" actress who plays C.Z. Guest in "Feud: Capote vs. the Swans": 2 wds. |
| 46% | MARGARETAVERY | 13 | Actress who plays Shug in "The Color Purple" who reunites with co-star Danny Glover in 28-Across (2 wds.) |
| 46% | ELLIEKEMPER | 11 | Actress who plays the lead role in 12-/24-Across: 2 wds. |
| 46% | NATALIEPORTMAN | 14 | "Black Swan" actress who plays a biologist in "Annihilation": 2 wds. |
| 46% | ANGELABASSETT | 13 | Actress who played rock star Tina Turner in the 1993 film "What's Love Got to Do With It": 2 wds. |
| 46% | MAYARUDOLPH | 11 | "Bridesmaids" actress who plays Christine in 32-Across: 2 wds. |
| 45% | MIREILLEENOS | 12 | "The Killing" actress who plays Marissa in 33-Across: 2 wds. |
| 45% | MOLLYRINGWALD | 13 | "Sixteen Candles" actress who plays Joanne Carson in "Feud: Capote vs. the Swans": 2 wds. |
| 45% | RACHELMCADAMS | 13 | "Spotlight" actress who plays surgeon Christine Palmer in 32-Across: 2 wds. |
| 45% | JACKIWEAVER | 11 | "Silver Linings Playbook" actress who plays Sandy in 32-Across: 2 wds. |
| 45% | JULIANNEMOORE | 13 | "Still Alice" actress who plays 19-Across later in life: 2 wds. |
| 45% | SANDRABULLOCK | 13 | "Speed" actress who played Lieutenant Lenina Huxley in 15-Across: 2 wds. |
| 44% | HAYLEYATWELL | 12 | "Agent Carter" actress who plays 18-Across's wife Evelyn in "Christopher Robin": 2 wds. |
| 44% | JULIECHRISTIE | 13 | "Shampoo" actress who played Lara in the 1965 film version of 19-Across: 2 wds. |
| 44% | LIVTYLER | 8 | "Armageddon" actress who played the lead singer's girlfriend Faye in 34-Across: 2 wds. |