| 100% | AMERICAN | 8 | With 28-Across, the first horse since 1978 to win the Triple Crown |
| 52% | AFFIRMED | 8 | Horse that won the Triple Crown in 1978 |
| 44% | HAYES | 5 | Actress Helen who was the first person to win the Triple Crown of Acting |
| 44% | JUSTIFY | 7 | Horse that won the Triple Crown in 2018 |
| 44% | CITATION | 8 | Horse that won the Triple Crown in 1948 |
| 44% | ASSAULT | 7 | Horse that won the Triple Crown in 1946 |
| 44% | VIOLA | 5 | Actress Davis who was the first African American to win the Triple Crown of Acting |
| 43% | WARCLOUD | 8 | First horse to compete in all three Triple Crown races |
| 43% | RIC | 3 | Flair who was the first wrestler to complete the WCW's Triple Crown |
| 42% | ASHLEIGHBARTY | 13 | Winner of the 2022 Australian Open, the first Australian woman to win a singles title there since 1978 (2 wds.) |
| 41% | ASSAULT | 7 | Horse that won the Triple Crown of Thoroughbred Racing in the US in 1946 |
| 41% | HOME | 4 | "Fun ___," Broadway play with the first female writing team to win the Tony Award for Best Score |
| 40% | TONYDUNGY | 9 | Hall-of-Famer who was the first Black head coach to win a 15 Across |
| 40% | THOMAS | 6 | With 65 Across, the first to see his name ''up in lights'' (1881) |
| 40% | JOEMAZZULLA | 11 | 28-Across head coach who is the youngest to win the NBA Finals since Bill Russell in 1969 (2 wds.) |
| 40% | GEORGIA | 7 | Team that defeated 15-Across to win the 2022 College Football Playoff National Championship, its first national title since 1980 |
| 40% | SECRETARIAT | 11 | Horse that won the US Triple Crown in 1973 |
| 40% | DIOMED | 6 | First horse to win the Epsom Derby in 1780 |
| 38% | MIRREN | 6 | Only person to have won the Triple Crown of Acting in both the U.S. and the U.K. |
| 38% | VIOLA | 5 | Davis who's the youngest person to win the "Triple Crown of Acting" |
| 37% | FOUROUT | 7 | With 38-Across, games required to win the World Series |
| 37% | JOHNNYMANZIEL | 13 | First freshman to win the 15-Across, in 2012: 2 wds. |
| 36% | HEY | 3 | With 61-Down, Jimi Hendrix's first single ... or a hint to the starts of 20-, 28-, 45- and 50-Across |
| 36% | HERNANDO | 8 | With 126-Across, first European to cross the Mississippi |
| 36% | ARCARO | 6 | Jockey who won the Triple Crown twice |
| 36% | ARCARO | 6 | Only jockey to win two Triple Crowns |
| 35% | MARIE | 5 | With 33-Across, first woman to win a Nobel Prize |
| 35% | MARIE | 5 | With 7-Across, first woman to win a Nobel Prize |
| 35% | CURIE | 5 | First woman to win the Nobel Prize |
| 35% | KATHRYN | 7 | With 38-Across, the only woman to win the Best Director Oscar (for "The Hurt Locker") |