| 100% | OUTER | 5 | With 30-Across, Amazon Prime sci-fi neo-Western series starring 17-Across, 42-Across, and Imogen Poots |
| 37% | JAMESBLISH | 10 | Sci-fi writer known for his "Cities in Flight" series and his "Star Trek" novels with 17-Across (2 wds.) |
| 34% | THEBOYS | 7 | Amazon Prime satirical superhero series starring Erin Moriarty, 15-Across, 21-Across, and 38-Across (2 wds.) |
| 34% | MONSTERSINC | 11 | Pixar film starring 17-Across and 30-Across adapted as a Disney+ series (2 wds.) |
| 31% | GOLIATH | 7 | Amazon Prime series starring Billy Bob Thornton and William Hurt |
| 31% | JURASSICWORLD | 13 | With 47-Across, 2018 sci-fi thriller starring 28-Across/30-Across and a lot of CGI dinosaurs (2 wds.) |
| 30% | STUFFEDTOMATOES | 15 | Rice-filled appetizers with red shells, and a hint to the words that bookend 17-, 30-, and 42-Across |
| 30% | BLOODSHOT | 9 | Superhero film starring 17-Across and 30-Across |
| 29% | CRIMINALMINDS | 13 | FBI drama starring A.J. Cook, 15-Across, and 30-Across that was revived with an "Evolution" series (2 wds.) |
| 29% | OMEGAMAN | 8 | 1971 movie starring 17- and 18-Across, with "The" |
| 29% | TENCOMMANDMENTS | 15 | 1956 movie starring 17- and 18-Across, with "The" |
| 29% | STARTREKPICARD | 14 | Sci-fi series starring 16-Across and 34-Across that debuted on CBS All Access on January 23, 2020 (3 wds.) |
| 29% | MODERN | 6 | "___ Love," Amazon Prime Video romantic comedy series starring Tina Fey and Dev Patel among others |
| 29% | GOODOMENS | 9 | Amazon series starring 15-Across/17-Across and 45-Across/47-Across based on a novel by Terry Pratchett and Neil Gaiman (2 wds.) |
| 29% | STARWARS | 8 | Sci-fi series with droids and lightsabers: 2 wds. |
| 29% | GOODADVICE | 10 | With 30-Down, what 17- and 62-Across are |
| 28% | PIECESOFHER | 11 | Netflix series starring 17-Across, 29-Across, and Bella Heathcote based on a novel by Karin Slaughter (3 wds.) |
| 28% | FIREFLY | 7 | Sci-fi western series about space that blends space travel and outlaw adventures |
| 28% | THESINNER | 9 | Anthology crime series starring Bill Pullman, 17-Across, and 28-Across (2 wds.) |
| 27% | ORANGEIS | 8 | With 32- and 35-Across, Netflix original series starring Taylor Schilling: 2 wds. |
| 27% | TRAX | 4 | "Time ___," sci-fi TV series starring Dale Midkiff and Elizabeth Alexander |
| 27% | MEANGIRLS | 9 | 2024 musical teen comedy written by Tina Fey starring 17-Across and 30-Across (2 wds.) |
| 27% | GETSHORTY | 9 | 1995 comedy film starring 17-Across and 30-Across based on an Elmore Leonard novel (2 wds.) |
| 27% | LANDOFTHE | 9 | 1968-70 US sci-fi television series starring Gary Conway and Don Matheson |
| 26% | STAR | 4 | With 58-Across, iconic 1960s sci-fi TV series |
| 26% | CLONE | 5 | With 17-Across, series of conflicts with battles on Ryloth, Felucia, Malastare, and Kamino |