| 100% | STUART | 6 | With 34-Across, E.B. White's kid-lit mouse, who made his big-screen debut in 1999 |
| 51% | WINNIETHEPOOH | 13 | A.A. Milne's kid-lit bear, who made his big-screen debut in 1966: Hyph. |
| 48% | CURIOUSGEORGE | 13 | The Reys' kid-lit monkey, who made his big-screen debut in 2006: 2 wds. |
| 43% | CURIOUSGEORGE | 13 | H.A. Rey monkey who made his big-screen debut in 2006 (2 wds.) |
| 35% | EDASNER | 7 | Actor who made his film debut in "Kid Galahad," 1962 |
| 35% | STREEP | 6 | Actress who made her big-screen debut in "Julia," 1977 |
| 34% | THEJOLLY | 8 | Mascot who made his Macy's Thanksgiving Day Parade debut in 2017 |
| 33% | SPONGEBOB | 9 | With 39-Across, Bikini Bottom fry cook who made his TV debut on May 1, 1999 |
| 33% | SETHMACFARLANE | 14 | Actor who starred in and made his directorial debut with 2012's "Ted": 2 wds. |
| 33% | DOOM | 4 | Doctor ___, Marvel's supervillain who made his debut in "Fantastic Four" |
| 32% | ICET | 4 | Actor who made his film debut in "Breakin'," 1984 |
| 32% | BRADLEYCOOPER | 13 | Actor who starred in and made his directorial debut with 2018's "A Star Is Born": 2 wds. |
| 32% | PATEL | 5 | Actor Dev who made his film debut in "Slumdog Millionaire" |
| 32% | GEORGECLOONEY | 13 | Actor who starred in and made his directorial debut with 2002's "Confessions of a Dangerous Mind": 2 wds. |
| 31% | PACINO | 6 | Oscar winner who made his film debut in "Me, Natalie," 1969 |
| 31% | EZRA | 4 | ___ Miller, an actor who made his debut in the film "Afterschool" |
| 31% | ELBA | 4 | Actor Idris who made his Coachella debut as a DJ in 2019 |
| 31% | DEPP | 4 | Johnny who made his film debut in "A Nightmare on Elm Street" |
| 31% | STYLES | 6 | Singer Harry who makes his acting debut in the upcoming movie "Dunkirk" |
| 31% | GEORGESMILEY | 12 | Long-running fictional hero who made his debut in "Call for the Dead" |
| 31% | CHER | 4 | Singer who made a comeback in 1999 with "Believe" |
| 30% | TAYE | 4 | Actor Diggs who made his film debut in "How Stella Got Her Groove Back" |
| 30% | URIE | 4 | Panic! at the Disco front man Brendon who made his Broadway debut in "Kinky Boots" |
| 30% | SERLING | 7 | Whom Spielberg made his directing debut with |
| 29% | STEPHEN | 7 | With 17 Across, justice who announced his retirement in 2022 |
| 29% | PAULDOWNS | 9 | "Broad City" comedian who makes his film debut in "Rough Night," which he also cowrote: 2 wds. |
| 29% | NEDBEATTY | 9 | "Network" Oscar nominee who made his film debut playing Bobby Trippe in the 1972 film "Deliverance" (2 wds.) |
| 29% | SEANPENN | 8 | Oscar winner who made his debut in an episode of Little House on the Prairie directed by his father |
| 29% | TYLER | 5 | With 34-Across, actor who played Madea in ten movies |
| 28% | THOMAS | 6 | With 65 Across, the first to see his name ''up in lights'' (1881) |