| 100% | KATEY | 5 | With 35-Across, "Sons of Anarchy" actress who plays the title character in "Rebel" |
| 64% | WARREN | 6 | With 35-Across, actor who played Clyde, one of the title characters on the run in 1967's "Bonnie and Clyde" |
| 63% | HANDL | 5 | Irene —, comedy actress who played the title character in 1970s ITV sitcom For the Love of Ada |
| 58% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 58% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |
| 57% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character in Netflix's "Ratched": 2 wds. |
| 57% | WHITE | 5 | Carol —, actress who played the title character in 1966 BBC TV play Cathy Come Home |
| 56% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 56% | FELICITY | 8 | With 55-Across, English actress who plays the first wife of 35-Across in "The Theory of Everything" |
| 55% | JAMESMCAVOY | 11 | "X-Men: Apocalypse" star who played the title character of 28-Across in a 2015 movie: 2 wds. |
| 55% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 54% | LILYCOLLINS | 11 | Actress who plays the title character on 46-Across (2 wds.) |
| 53% | EVA | 3 | Actress Green who played the title character in "Miss Peregrine's Home for Peculiar Children" |
| 53% | CAMILLERAZAT | 12 | Actress who plays the title character's new friend on 46-Across (2 wds.) |
| 53% | ROBERTDENIRO | 12 | "Joy" actor who plays the title character in 18-Across: 3 wds. |
| 52% | MICHELLE | 8 | With 27-Down, actress who plays the wife of 15-Across in "The Greatest Showman" |
| 52% | LOUISAHARLAND | 13 | "Derry Girls" actress who plays the title character on 44-Across (2 wds.) |
| 52% | SOFIA | 5 | ___ Hublitz, actress who plays the character of Charlotte Byrde in Netflix's "Ozark" |
| 52% | LINNEY | 6 | Laura ___, actress who plays the character of Wendy Byrde in Netflix's "Ozark" |
| 52% | EMERY | 5 | Lisa ___, actress who plays the character of Darlene Snell in Netflix's "Ozark" |
| 52% | GARNER | 6 | Julia ___, actress who plays the character of Ruth Langmore in Netflix's "Ozark" |
| 52% | LESLIEJONES | 11 | Actress who plays the mother of Prince Akeem's son in "Coming 2 America": 2 wds. |
| 52% | MARLA | 5 | ___ Pennington, actress who played the character of Joan Lawson in the sitcom "Small Wonder" |
| 52% | DAWN | 4 | Actress French who played the title role in "The Vicar of Dibley" |
| 51% | PETERDINKLAGE | 13 | "Game of Thrones" actor who plays the title character in "The Toxic Avenger": 2 wds. |
| 51% | BARBARABARRIE | 13 | "Breaking Away" actress who played the title character's Nana on 46-Across (2 wds.) |
| 51% | HOLMES | 6 | Brittany Ashton ___, actress who played the character of Darla in the 1994 movie "The Little Rascals" |
| 51% | THOMPSON | 8 | Lea ___, actress who played the character of Ms. Roberts in the 1994 movie "The Little Rascals" |
| 51% | TIFFANY | 7 | ___ Brissette, actress who played the character of V.I.C.I in the sitcom "Small Wonder" |