| 100% | WARREN | 6 | With 35-Across, actor who played Clyde, one of the title characters on the run in 1967's "Bonnie and Clyde" |
| 64% | DANIELKALUUYA | 13 | Actor who plays Slim, one of the title characters on the run in 2019's "Queen & Slim": 2 wds. |
| 57% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 51% | KATEY | 5 | With 35-Across, "Sons of Anarchy" actress who plays the title character in "Rebel" |
| 48% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 45% | JUSTIN | 6 | With 35-Across, actor who plays Riley Poole in the "National Treasure" films and Disney+ series |
| 43% | ROBINWILLIAMS | 13 | Actor who played Daniel Hillard, and the title character, in the 1993 film "Mrs. Doubtfire": 2 wds. |
| 43% | TIMOTHEE | 8 | With 35-Across, "Little Women" actor who plays the lead character Paul Atreides in "Dune" |
| 43% | KENNETHBRANAGH | 14 | Actor who directed and played the title character in 1996's "Hamlet": 2 wds. |
| 42% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 42% | PETERSELLERS | 12 | Actor who played Pres. Merkin Muffley, Group Capt. Lionel Mandrake, and the title character in 32-Across: 2 wds. |
| 42% | CHAR | 4 | Actor who played a character with the same first name on "Two and a Half Men" |
| 42% | MYERS | 5 | Mike —, actor who played the title role in films Wayne's World and Austin Powers: International Man of Mystery |
| 42% | BRYANCRANSTON | 13 | "Trumbo" actor who plays the owner of the Big Top Mall in "The One and Only Ivan" (2 wds.) |
| 41% | CHANNINGTATUM | 13 | Actor who plays one of the studio's stars in 18-Across: 2 wds. |
| 41% | HARRISONFORD | 12 | "The Fugitive" actor who plays the title role in "Indiana Jones and the Dial of Destiny" (2 wds.) |
| 41% | EDDIE | 5 | With 17-Across, English actor who plays 35-Across in "The Theory of Everything" |
| 41% | CLARKGREGG | 10 | Actor who plays the character of Phil Coulson, a S.H.I.E.L.D agent in "Captain Marvel": 2 wds. |
| 40% | PETERDINKLAGE | 13 | "Game of Thrones" actor who plays the title character in "The Toxic Avenger": 2 wds. |
| 40% | JOHNSLATTERY | 12 | "Mad Men" actor who appears in one of the stories on 27-Across (2 wds.) |
| 40% | KEIR | 4 | Andrew —, actor who played the title role in 1967 sci-fi film Quatermass and the Pit |
| 40% | READ | 4 | Actor James who plays Clyde Weston on the still-running "Days of Our Lives" |
| 40% | CHRIS | 5 | With 35-Across, actor who played Ransom in the 2019 murder mystery "Knives Out" |
| 40% | PAULSCHNEIDER | 13 | Actor who played the role of Mark Brendanawicz in "Parks and Recreation", a character that appeared only in the first two seasons: 2 wds. |
| 40% | SKYLAR | 6 | ___ Gaertner, actor who plays the character of Jonah Byrde in Netflix's "Ozark" |
| 39% | BRAD | 4 | With 34-Across, "Moneyball" actor who plays a rescuer of the novelist in "The Lost City" |
| 39% | ETHAN | 5 | ___ Hawke, actor who played the character of Todd Anderson in "Dead Poet's Society" |
| 39% | MICHAEL | 7 | With 17-Across, "Masters of Sex" actor who plays the angel Aziraphale on 30-Across |