| 100% | TENDAYSIN | 9 | With 37-Across, new ABC series about a TV producer whose daughter goes missing: 3 wds. |
| 36% | DRIVETO | 7 | With 37-Across, subtitle of a hit Netflix documentary series about Formula 1 racing (2 wds.) |
| 34% | NATHANFILLION | 13 | "Firefly" actor who plays Officer John Nolan on an ABC series about a new LAPD cop (2 wds.) |
| 32% | WHEREWEBELONG | 13 | Emily Giffin novel about a television producer reunited with the daughter she gave up for adoption (3 wds.) |
| 29% | MONK | 4 | TV series about a detective with OCD |
| 29% | THEREALMCCOYS | 13 | Comedy series about a West Virginia family relocating to a farm in California that premiered on ABC in 1957 (3 wds.) |
| 29% | DEMILOVATO | 10 | "Heart Attack" singer whose first TV series lead role was on the Disney Channel's "Sonny with a Chance": 2 wds. |
| 28% | GLEE | 4 | TV series about a high school club called New Directions |
| 28% | YOUR | 4 | With 37- and 39-Across, book and TV series on human evolution, and a hint to the circled letters |
| 28% | ISITSAFE | 8 | Usual query about a new medication: 3 wds. |
| 28% | THEGOODDOCTOR | 13 | ABC's medical drama TV series starring Freddie Highmore, based on a South Korean series of the same name: 3 wds. |
| 28% | THESILVERARROW | 14 | Lev Grossman novel about a girl whose rich uncle sends her a steam locomotive with special powers (3 wds.) |
| 27% | LIVINGWITH | 10 | With 28-Across, Netflix series about a man and his clone: 2 wds. |
| 27% | SHOW | 4 | "The Morning ___," series about a breakfast news program, starring Jennifer Aniston and Reese Witherspoon on Apple TV+ |
| 27% | KIPOANDTHEAGE | 13 | With 32-Across, animated series about a girl from beneath the Earth's surface: 4 wds. |
| 27% | THEMUPPETS | 10 | ABC series focusing on the fictional talk show "Up Late With Miss Piggy": 2 wds. |
| 27% | THEHOUSEOF | 10 | "___ Flowers," Spanish language comedy-drama series about a dysfunctional Mexican family that owns a flower shop: 3 wds. |
| 27% | MEANSTREAK | 10 | 2014 Sandra Brown bestseller about a doctor who goes missing in the mountain wilderness: 2 wds. |
| 27% | RICKANDMORTY | 12 | Animated sitcom on Adult Swim about a mad scientist's escapades with his grandson: 3 wds. |
| 27% | LIFEOFPI | 8 | Book and movie about a boy on a boat with a tiger: 3 wds. |
| 27% | DEAREVANHANSEN | 14 | 2017 Tony-winning musical about a teenager with a social anxiety disorder: 3 wds. |
| 26% | TEENWOLF | 8 | Supernatural TV series about a lycanthrope at Beacon Hills High (2 wds.) |
| 26% | REGRETTINGYOU | 13 | 2019 bestseller by 41-Across about a mother and daughter coping with a family tragedy (2 wds.) |
| 26% | ICANTGO | 7 | With 37-Across, 1982 #1 single by 41-Across: 3 wds. |
| 26% | CITYSLICKERS | 12 | Comedy film starring 42-Across as a New Yorker who goes on a cattle drive with his friends (2 wds.) |
| 26% | GONEBABYGONE | 12 | 1998 18-Across novel about a missing woman that was made into a 2007 Ben Affleck film: 3 wds. |
| 26% | WESTWORLD | 9 | Sci-fi TV series about a resort with robots |
| 26% | MEREDITHGREY | 12 | ABC TV character with a colorful last name, played by Ellen Pompeo since 2005: 2 wds. |
| 26% | HOUSEONTHE | 10 | "Little ___ Prairie," NBC TV series about a family living on a farm in the 1870s that ran from 1974 - 1983: 3 wds. |
| 26% | KEVINPROBABLY | 13 | With 33-Across, ABC series starring Jason Ritter as a man tasked with a heavenly mission: 2 wds. |