| 100% | SANDRA | 6 | With 40-Across, actress who played Kate opposite Keanu Reeves in "The Lake House" |
| 57% | CARRIEANNEMOSS | 14 | Actress who played Trinity opposite Keanu Reeves in "The Matrix": 2 wds., hyph. |
| 53% | CHARLIZETHERON | 14 | Actress who played Sara opposite Keanu Reeves in "Sweet November": 2 wds. |
| 52% | ALIWONG | 7 | Actress who played Sasha opposite Keanu Reeves in "Always Be My Maybe": 2 wds. |
| 45% | MICHAEL | 7 | With 40-Across, singer who played the Scarecrow in "The Wiz" |
| 42% | MARYJ | 5 | With 40-Across, "The Wiz Live!" actress who plays Florence in "Mudbound": 2 wds. |
| 42% | MICHELLE | 8 | With 45-Across, actress who played Catwoman in the 1992 film "Batman Returns" |
| 41% | LEONI | 5 | Tea —, actress who played Kate Reynolds in 2000 comedy-drama film The Family Man |
| 41% | SOPHIE | 6 | With 40-Across, "Game of Thrones" actress whose family adopted the dog that played her direwolf in the series |
| 41% | RYAN | 4 | Meg —, actress who played the female lead in 2001 comedy Kate & Leopold |
| 40% | EVELYNKEYES | 11 | Actress who played Suellen O'Hara in the film "Gone With the Wind": 2 wds. |
| 40% | VICKILAWRENCE | 13 | Actress who played Mama Thelma Harper in "The Family" skits with 38-Across (2 wds.) |
| 40% | MICHELLE | 8 | With 27-Down, actress who plays the wife of 15-Across in "The Greatest Showman" |
| 40% | THOMSETT | 8 | Sally —, actress who played Jo in 1970s ITV sitcom Man About the House |
| 40% | WRAGG | 5 | Kaye —, actress who played Lucy Archer in BBC TV drama series The Lakes |
| 40% | SONJASOHN | 9 | "The Wire" actress who plays Nancy, the title boxer's mother, in a 2023 biopic about 40-Across (2 wds.) |
| 40% | CHURM | 5 | Sarah —, actress who played Sarah Braithwaite in ITV series At Home with the Braithwaites |
| 40% | SARAH | 5 | & 8D Actress who played Sarah Braithwaite in ITV series At Home with the Braithwaites |
| 40% | LUPITA | 6 | With 42-Across, actress who played Maz Kanata from the planet Takodana in 2015's "Star Wars: The Force Awakens" |
| 39% | LORILOUGHLIN | 12 | Actress who plays Rebecca Donaldson-Katsopolis, Jesse's wife in the 1987 sitcom "Full House": 2 wds. |
| 39% | SMART | 5 | Sarah —, actress who played Virginia Braithwaite in 2000s ITV series At Home with the Braithwaites |
| 39% | LIZTAYLOR | 9 | Actress who played opposite Dick Burton in 11-Across |
| 39% | ANDREABARBER | 12 | Actress who played Kimmy Gibbler, D.J's best friend in the 1987 sitcom "Full House:" 2 wds. |
| 39% | FEE | 3 | Melinda O —, actress who played Dr Kate Westin in 1970s US television series The Invisible Man |
| 39% | JEWEL | 5 | Singer and actress who played Sue Lee Shelley in 1999 film drama Ride with the Devil |
| 39% | DAKOTAFANNING | 13 | "The Twilight Saga" actress who plays Sara Howard in 40-Across (2 wds.) |
| 39% | MAGGIE | 6 | With 34-Across, "Psych" actress who plays the mother in 18-Across |
| 39% | ANGELABASSETT | 13 | Actress who plays Tina Turner in the music biopic "What's Love Got to Do with It" (2 wds.) |