| 100% | APPLES | 6 | With 51-Across, 2021 Liane Moriarty novel about a matriarch who mysteriously disappears |
| 53% | WHATALICE | 9 | With 19-Across, 2009 Liane Moriarty novel about a mother who develops amnesia: 2 wds. |
| 34% | HELLOSTRANGER | 13 | Katherine Center novel about a portrait artist who is diagnosed with face blindness (2 wds.) |
| 33% | LILYANDDUNKIN | 13 | Donna Gephart young adult novel about a transgender teenager who befriends a classmate with bipolar disorder (3 wds.) |
| 33% | HOWTOWALKAWAY | 13 | Katherine Center novel about a plane crash survivor who falls in love with her physical therapist (4 wds.) |
| 32% | RICHARD | 7 | With 19 Across, billionaire who took a notable vacation in July 2021 |
| 31% | THESURGEON | 10 | 2001 Tess Gerritsen novel about homicide detective Jane Rizzoli, who's hunting a murderer with medical skills: 2 wds. |
| 31% | THETORNSKIRT | 12 | Novel by 47-Across about a high schooler who becomes obsessed with a homeless girl (3 wds.) |
| 31% | HALFPOUND | 9 | With 51 Across, ''big'' beef on a bun |
| 30% | NEVERWHERE | 10 | 39-Across novel about a Scottish man who travels through London Below |
| 30% | WELCOMETO | 9 | With 51-Across, humorous podcast about a fictional small town beset by mysterious conspiracies: 2 wds. |
| 30% | BIGLITTLELIES | 13 | 2014 Liane Moriarty novel about suburban women confronting domestic abuse: 3 wds. |
| 30% | CARRIE | 6 | Horror novel about a girl with telekinetic powers |
| 30% | DEENIE | 6 | Judy Blume novel about a girl with scoliosis |
| 29% | NICHOLAS | 8 | With 62 Across, Charles Dickens novel about a man trying to support his sister and widowed mother, featuring a Maine college |
| 29% | SMILE | 5 | Raina Telgemeier graphic novel about a girl with braces |
| 29% | GIVER | 5 | Dystopian 1993 novel about a colorless world, with "The" |
| 29% | IDIOT | 5 | Dostoyevsky novel about a "positively beautiful man," with "The" |
| 29% | DRUNKONLOVE | 11 | Jasmine Guillory novel about a Napa Valley winery co-owner who has a one-night stand with the winery's newest hire, featuring a North Carolina university |
| 29% | AMILLIONJUNES | 13 | Emily Henry novel about a young woman who finds a connection with the son of her family's enemy when he returns home one summer (3 wds.) |
| 29% | CORALINE | 8 | 39-Across novel about a girl who goes through a forbidden door |
| 29% | INSOMNIA | 8 | Stephen King novel about a man with a sleep disorder |
| 29% | LEAKHOUSE | 9 | Charles Dickens novel about a residence with constant plumbing problems? |
| 29% | YOUNGJANEYOUNG | 14 | Novel by 44-Across about a political intern who changes her identity when an affair with her boss becomes public (3 wds.) |
| 28% | STARDUST | 8 | 39-Across novel about a half-Faerie boy who rescues a girl who falls from the sky |
| 28% | PERSUASION | 10 | Novel by 18-Across about Anne Elliot, a young woman who marries a ship's captain |
| 27% | BRETT | 5 | With 33-Across, former Packers quarterback who made a cameo in "There's Something About Mary" |
| 27% | BABYPROOF | 9 | Emily Giffin novel about a happy couple who argue over having children (2 wds.) |
| 27% | RISEANDSHINE | 12 | 43-Across novel about a morning talk show host who is fired because of an on-air gaffe (3 wds.) |
| 27% | LOONSTRUCK | 10 | Film about a diving bird who collides with a snorkeler? |