| 100% | THURGOOD | 8 | With 52-Across, Supreme Court justice who's the title role played by Chadwick Boseman in a 2017 biopic |
| 38% | JAMES | 5 | With 50-Across, soul singer played by Chadwick Boseman in the 2014 biopic "Get On Up" |
| 37% | ROD | 3 | Actor Steiger who played the title role of 15-Across in a 1959 biopic |
| 37% | AMELIA | 6 | Title role played by Hilary Swank in a 2009 biopic |
| 36% | DRWHO | 5 | BBC classic whose title role will be played by a woman for the first time in 2017 |
| 36% | JACKIEROBINSON | 14 | Baseball superstar played by Chadwick Boseman in the 2013 biopic "42": 2 wds. |
| 34% | RBG | 3 | Supreme Court Justice played by Felicity Jones in "On the Basis of Sex," familiarly |
| 33% | TOTO | 4 | Role played by a dog with a bigger salary than some human actors in the same film |
| 33% | BEN | 3 | Actor Gazzara who played the title role of 15-Across in a 1975 film |
| 32% | PATTINSON | 9 | Robert who plays the title role in 22 Across |
| 32% | LILO | 4 | Title role played by Maia Kealoha in a 2025 remake |
| 32% | LEONARDO | 8 | With 52-Across, "The Revenant" Oscar winner who plays actor Rick Dalton in "Once Upon a Time in Hollywood" |
| 31% | LARRYPARKS | 10 | Actor who played the title role in 1946 biopic The Jolson Story |
| 31% | REEVES | 6 | Steve who played the title role of Hercules in a 1959 film |
| 31% | CHARLIEWILSON | 13 | Title role played by Tom Hanks in a 2007 comedy-drama: 2 wds. |
| 31% | LARRYCROWNE | 11 | Title role played by Tom Hanks in a 2011 romantic comedy: 2 wds. |
| 31% | FORRESTGUMP | 11 | Title role played by Tom Hanks in a 1994 Oscar-winning movie: 2 wds. |
| 31% | JASON | 5 | With 36-Across, Honolulu-born actor who played the title role in "Aquaman" |
| 31% | JOELMCCREA | 10 | US actor who played the title role in 1944 biopic Buffalo Bill |
| 31% | LOLITA | 6 | & 25A Actress who played the title role in 1989 biopic Blaze |
| 31% | ANTHONY | 7 | With 38-Across, actor who played baseball's Jim Piersall in the 1957 biopic "Fear Strikes Out" |
| 31% | ERROL | 5 | & 8D Actor who played the title role in 1942 biopic Gentleman Jim |
| 30% | JESSEPINKMAN | 12 | Character played by Aaron Paul in "Breaking Bad", who was a crystal meth dealer and worked with the character played by 30-Across: 2 wds. |
| 30% | DANNYKAYE | 9 | Comic actor who played the title role in the 1955 film The Court Jester |
| 30% | NERO | 4 | Role played by 52-Across in "The Story of Mankind" |
| 30% | TONYA | 5 | Skater Harding played by Margot Robbie in a 2017 biopic |
| 30% | CHRISTOPHER | 11 | ___ Walken, actor who made a cameo in "Pulp Fiction" by playing the role of an ex-soldier |
| 30% | JIM | 3 | With 28-Across, "Mr. Popper's Penguins" star who plays the title role in 15-Across |
| 30% | HAYEK | 5 | Salma —, actress who played the title role in 2002 biopic Frida |