| 100% | VENA | 4 | With 52-Down, passage to the heart |
| 58% | ASMALL | 6 | With 52-Across, answer to the riddle |
| 56% | CAVA | 4 | Vena ___ (passage to the heart) |
| 55% | LOUNGE | 6 | Room with a secret passage to the Conservatory |
| 53% | STUDY | 5 | Clue room with a secret passage to the kitchen |
| 52% | ASHOTIN | 7 | With 52-Across, wild guess ... or what the answer to each starred clue has? |
| 52% | STUDY | 5 | Room with a secret passage to the kitchen in the board game Clue |
| 51% | PISA | 4 | With 52-Down, home of the Leaning Tower |
| 50% | LOUNGE | 6 | Room in Clue with a secret passage to the Conservatory |
| 50% | LEOPARD | 7 | According to Isaiah, it "shall lie down with the kid" |
| 50% | CHOU | 4 | With 52-Down, 39-Across leader from 1949 to 1976 |
| 50% | INLET | 5 | Passage to the sea |
| 50% | EVERYMOTHERSSON | 15 | Group with the 1967 hit "Come On Down to My Boat" |
| 49% | RIB | 3 | With 52 Down, beef dinner |
| 49% | HEYJUDE | 7 | 1968 song with the lyric "Remember to let her into your heart" |
| 48% | VENACAVA | 8 | Vessel to the heart |
| 48% | CARDIAC | 7 | Relating to the heart |
| 48% | CENTRALIZE | 10 | "take to the heart" |
| 47% | ESOBESO | 7 | 1962 hit with the lyric "Like the samba sound, my heart begins to pound" |
| 47% | CAVA | 4 | Vena ___ (vessel to the heart) |
| 47% | VEIN | 4 | Blood vessel to the heart |
| 47% | VENA | 4 | ___ cava (path to the heart) |
| 47% | AORTA | 5 | Blood supplier to the heart |
| 47% | VENACAVA | 8 | Blood vessel to the heart |
| 47% | VEIN | 4 | It goes to the heart |
| 47% | CORONARY | 8 | Relating to the heart arteries |
| 47% | VENA | 4 | __ cava (path to the heart) |
| 47% | HUG | 3 | Hold close to the heart |
| 47% | DOUBLE | 6 | With 52-Down, betrayal, and what's formed by each pair of the trigrams |
| 47% | PLAY | 4 | With 79-Down, something to do in the yard |