| 100% | FIRST | 5 | With 9-Across, part one of the Moderna and Pfizer vaccines |
| 46% | SPLITENDS | 9 | Hair problem ... which can describe the last parts of 9 and 11 Across |
| 44% | GASPAR | 6 | One of the Magi, along with Melchior and Balthazar |
| 44% | ATHOS | 5 | One of the Three Musketeers, along with Porthos and Aramis |
| 44% | PAPA | 4 | One of the Three Bears, along with Mama and Baby |
| 44% | IRON | 4 | With 21 Across, one of the Avengers |
| 43% | FATS | 4 | One of the three main macronutrients, along with carbohydrates and proteins |
| 43% | ABC | 3 | One of the Big Three networks, along with NBC and CBS |
| 43% | AIR | 3 | One of the four classical elements, along with fire, earth, and water |
| 43% | AER | 3 | One of the four classical elements, along with ignis, aqua and terra |
| 42% | AOL | 3 | One of the former Big Three information services, along with CompuServe and Prodigy |
| 42% | STRINGSATTACHED | 15 | What some favors and one part of the answers to 17-, 23-, 46-, and 57-Across come with? |
| 42% | THOMAS | 6 | With 9 Down and 71 Across, source of quote |
| 42% | CLARITY | 7 | One of the four C's of diamonds (along with cut, color, and carat) |
| 42% | DANTE | 5 | One of the so-called "Three Crowns of Florence," along with Petrarch and Boccaccio |
| 42% | LAOS | 4 | One of the three landlocked countries with four-letter names, aside from Chad and Mali |
| 41% | WELCOMETOMY | 11 | With 59-Across, what one might say when entering the starts of 16-, 24-, and 38-Across? |
| 41% | FIRE | 4 | I'm one of the classical elements who is associated with heat and dryness |
| 41% | SANTA | 5 | With the first parts of 17- and 52-Across and 11- and 25-Down, four California cities |
| 40% | NINA | 4 | One of Columbus's ships, along with the Pinta and the Santa Maria |
| 40% | ARM | 3 | Part of the body with the humerus and radius |
| 40% | TORSO | 5 | Part of the body with the chest and abdomen |
| 40% | GROUCHO | 7 | Part of the Marx brothers with Chico and Harpo |
| 40% | RHETORIC | 8 | Part of the trivium, along with grammar and logic |
| 40% | METALLICA | 9 | One of the greatest metal bands of all time with hits like "Enter Sandman" and "Nothing Else Matters" |
| 40% | BOOBY | 5 | With 127 Across, one of many devices thwarting the burglars in "Home Alone" |
| 40% | RNA | 3 | Messenger ___ (what the Pfizer and Moderna vaccines use) |
| 40% | NOSE | 4 | Part of the body associated with sneezing, sniffling and snoring |
| 40% | DREYFUS | 7 | One of the most successful comedians, Julia Louis-___, who starred in "Seinfeld" and was once a part of SNL |
| 40% | SUPER | 5 | Word that can precede the first parts of 15- and 61-Across and 9- and 27-Down |