| 100% | PSYCHOTIC | 9 | With a mental condition that detaches from reality |
| 42% | ACNE | 4 | Condition that may be treated with a cream |
| 38% | MAMMAL | 6 | Class with a name that comes from the Latin word for "breast" |
| 37% | OTTER | 5 | Playful aquatic mammal with a name that comes from the same root as water |
| 37% | CHIPS | 5 | With 18a, fries that are a popular combination from England |
| 37% | FISH | 4 | With 47a, seafood that is a popular combination from England |
| 37% | OOBLECK | 7 | Gooey substance made of cornstarch and water, with a name that comes from Dr. Seuss |
| 36% | INERT | 5 | With 3-Down, those you're quite unlikely to get a reaction from? |
| 36% | ABSTRACT | 8 | In art, a style that deviates from reality |
| 36% | DENIM | 5 | Material with a name that comes from a shortening of the French for "serge from Nîmes" |
| 36% | LALA | 4 | In __ land; detached from reality |
| 36% | IBERIA | 6 | Airline with a hub in Madrid that will fly you direct from there to Washington, DC |
| 35% | BONE | 4 | Ribs feature that's absent (along with rib meat) from a McRib sandwich |
| 35% | RANSOM | 6 | Kind of note that might be written with letters clipped from a magazine |
| 35% | MENSAN | 6 | Person with a mental bloc? |
| 34% | MOE | 3 | Flaming ___, fictional cocktail drink from "The Simpsons" that shares a name with the series' bartender |
| 34% | UNHITCH | 7 | Detach from a trailer |
| 34% | WARIO | 5 | Nintendo antagonist with a yellow hat, a zigzag mustache, and a name one letter off from that of the protagonist |
| 33% | SOCIOPATH | 9 | One with a mental health disorder, no conscience |
| 33% | WILD | 4 | '"Man vs. ___," adventure reality TV series that follows Bear Grylls' attempts to escape from a remote location |
| 33% | TIDYING | 7 | "___ Up with Marie Kondo," reality TV series starring a Japanese organizing consultant that was released in 2019 |
| 33% | PINATA | 6 | Container hung from a height filled with treats that's broken as part of celebrations in Mexico |
| 33% | OVERALLS | 8 | Jumpsuit-style denim wear from the '90s with adjustable straps that has become a popular fashion trend |
| 33% | WEANS | 5 | Detaches from a source of dependence |
| 33% | INSOMNIA | 8 | Condition that prevents people from sleeping |
| 33% | AUTISM | 6 | Condition that exists on a spectrum |
| 33% | ACNE | 4 | Condition that a dermatologist might treat |
| 33% | WEAN | 4 | Detach from a source of dependence |
| 33% | LUCYINTHESKY | 12 | With 38-Across, a track from 15-Across, sung by Lennon, that faced several controversies about its initials: 4 wds. |
| 33% | AREYOUTHEREGOD | 14 | With 49-Across, 2023 movie starring Abby Ryder Fortson that was adapted from a 1970 Judy Blume novel: 4 wds. |