| 100% | MEANS | 5 | With which an end is achieved |
| 45% | TAMA | 4 | ___ Art University Library, academic library with two locations which is considered an architectural wonder |
| 43% | FERMIUM | 7 | Element with atomic the number 100 which was named after an Italian-American pioneer of nuclear physics |
| 43% | BROGUE | 6 | With which Seamus will rub ego |
| 43% | DARTS | 5 | Game in which the object is to end with zero points |
| 43% | AVEC | 4 | French word for "with" which is also an anagram for cave |
| 43% | TWILIGHT | 8 | "___ Zone," one of the most popular thriller TV shows, which is an anthology series dealing with the macabre |
| 42% | RED | 3 | ___ Leicester, an English cheese named after the city of Leicester, which was originally colored with carrot or beetroot juice |
| 42% | HOTTOGO | 7 | Chappell Roan hit with an accompanying dance in which the letters of the song's name are spelled out |
| 42% | CHEMICALBALANCE | 15 | It can be achieved with nutrition |
| 42% | GRAPE | 5 | Berry with which wine is made |
| 41% | AMEN | 4 | Word with which every prayer ends |
| 41% | RENOUNCE | 8 | End an association with |
| 41% | ADDED | 5 | which were an ___ distraction. |
| 41% | EARRING | 7 | "Girl with a Pearl ___," an oil painting by Dutch painter Johannes Vermeer which is housed in the Mauritshuis, The Hague |
| 41% | EASYA | 5 | No-brainer class, an example of which is named by combining the ends of 20-, 36-, 42- and 55-Across |
| 41% | OPENSESAME | 10 | Words with which to make an entrance? |
| 40% | RAMADA | 6 | Spanish name for an open porch, often roofed with branches, after which a hotel chain that started in Arizona, was named |
| 40% | POUTYLIPS | 9 | Look that might be achieved with a plumper |
| 40% | HOLI | 4 | Celebration with which the beverage bhang is associated |
| 40% | ASTHMA | 6 | Affliction for which an inhaler may be prescribed |
| 40% | ATIMETOKILL | 11 | 1996 crime drama for which 34-Across was honored with an NAACP Image Award (4 wds.) |
| 40% | COACHCARTER | 11 | 2005 sports drama for which 34-Across was honored with an NAACP Image Award (2 wds.) |
| 40% | ONELEG | 6 | On which an arabesque is performed |
| 40% | RELAYRACE | 9 | An anchor is at its end |
| 40% | BOW | 3 | An arrow is shot with one |
| 40% | HUGSITOUT | 9 | Ends a conflict with an embrace |
| 40% | GEEK | 4 | Be an enthusiastic dweeb, with "out" |
| 40% | SONOFMAN | 8 | Magritte work in which a face is obscured by an apple, with The |
| 40% | SAND | 4 | "Love Letters in the ___," song with an ocean-related word in the title, a version of which was sung by Pat Boone |